Abstract：
BACKGROUND: Obstructive sleep apnea complicates 10% to 32% or greater of pregnancies, however, reports on long-term effects on the children of pregnancies affected by obstructive sleep apnea are limited.
OBJECTIVE: We sought to test the hypothesis that the children of pregnant people with symptoms of obstructive sleep apnea during pregnancy have an increased incidence of autism spectrum disorder.
METHODS: This was a case-control study comparing the pregnancies of people whose children were later diagnosed with autism spectrum disorder without a known associated genetic condition to those whose children were diagnosed with autism spectrum disorder with a known associated genetic condition.
RESULTS: Of the 51 total parents who were eligible and consented to participate, 4 had a child with autism associated with a known genetic condition, and 47 had a child with autism with no known genetic condition. The prevalence of any snoring (50.0% and 36.2%, respectively) and daytime tiredness (75.0% and 89.4%, respectively) were similar between both groups.
CONCLUSIONS: In this study, the prevalence of any snoring and falling asleep while driving during pregnancy was higher in the sampled population than typically reported in pregnant people. While the sample size for this study was small, our preliminary results suggest that parents of children with autism have a high prevalence of sleep-related concerns during their pregnancies, which indicates the need for further investigation - especially for obstructive sleep apnea. Future studies exploring the neurodevelopmental outcomes of children of a cohort of pregnant people with known presence or absence of obstructive sleep apnea during pregnancy is warranted.
OBJECTIVE: We sought to test the hypothesis that the children of pregnant people with symptoms of obstructive sleep apnea during pregnancy have an increased incidence of autism spectrum disorder.
METHODS: This was a case-control study comparing the pregnancies of people whose children were later diagnosed with autism spectrum disorder without a known associated genetic condition to those whose children were diagnosed with autism spectrum disorder with a known associated genetic condition.
RESULTS: Of the 51 total parents who were eligible and consented to participate, 4 had a child with autism associated with a known genetic condition, and 47 had a child with autism with no known genetic condition. The prevalence of any snoring (50.0% and 36.2%, respectively) and daytime tiredness (75.0% and 89.4%, respectively) were similar between both groups.
CONCLUSIONS: In this study, the prevalence of any snoring and falling asleep while driving during pregnancy was higher in the sampled population than typically reported in pregnant people. While the sample size for this study was small, our preliminary results suggest that parents of children with autism have a high prevalence of sleep-related concerns during their pregnancies, which indicates the need for further investigation - especially for obstructive sleep apnea. Future studies exploring the neurodevelopmental outcomes of children of a cohort of pregnant people with known presence or absence of obstructive sleep apnea during pregnancy is warranted.
摘要：
背景：阻塞性睡眠呼吸暂停使10％至32％或更多的妊娠复杂化，然而,有关阻塞性睡眠呼吸暂停对妊娠儿童的长期影响的报道有限.
目的：我们试图验证以下假设：妊娠期间出现阻塞性睡眠呼吸暂停症状的孕妇的孩子自闭症谱系障碍的发生率增加。
方法：这是一项病例对照研究，比较了孩子后来被诊断为自闭症谱系障碍而没有已知相关遗传条件的人的怀孕情况和孩子被诊断为自闭症谱系障碍而已知相关遗传条件的人的怀孕情况。
结果：在有资格并同意参加的51名父母中，4有一个患有自闭症的孩子，与已知的遗传状况有关，47岁的孩子患有自闭症，没有已知的遗传条件。任何打鼾的患病率(50.0%和36.2%，分别)和白天疲劳(75.0%和89.4%，两组之间分别)相似。
结论：在这项研究中，在怀孕期间开车时打鼾和入睡的患病率在抽样人群中高于通常报告的孕妇。虽然这项研究的样本量很小，我们的初步结果表明，自闭症儿童的父母在怀孕期间与睡眠相关的担忧患病率很高，这表明需要进一步研究-特别是阻塞性睡眠呼吸暂停。有必要进行未来的研究，以探索怀孕期间已知存在或不存在阻塞性睡眠呼吸暂停的孕妇队列中儿童的神经发育结局。
目的：我们试图验证以下假设：妊娠期间出现阻塞性睡眠呼吸暂停症状的孕妇的孩子自闭症谱系障碍的发生率增加。
方法：这是一项病例对照研究，比较了孩子后来被诊断为自闭症谱系障碍而没有已知相关遗传条件的人的怀孕情况和孩子被诊断为自闭症谱系障碍而已知相关遗传条件的人的怀孕情况。
结果：在有资格并同意参加的51名父母中，4有一个患有自闭症的孩子，与已知的遗传状况有关，47岁的孩子患有自闭症，没有已知的遗传条件。任何打鼾的患病率(50.0%和36.2%，分别)和白天疲劳(75.0%和89.4%，两组之间分别)相似。
结论：在这项研究中，在怀孕期间开车时打鼾和入睡的患病率在抽样人群中高于通常报告的孕妇。虽然这项研究的样本量很小，我们的初步结果表明，自闭症儿童的父母在怀孕期间与睡眠相关的担忧患病率很高，这表明需要进一步研究-特别是阻塞性睡眠呼吸暂停。有必要进行未来的研究，以探索怀孕期间已知存在或不存在阻塞性睡眠呼吸暂停的孕妇队列中儿童的神经发育结局。
