PDF(Pubmed)
Abstract：
UNASSIGNED: In spring 2022, a series of reports from the United Kingdom and the United States identified an increase in the incidence of acute severe hepatitis in children. The Public Health Agency of Canada (PHAC) collaborated with provincial/territorial health partners to investigate in Canada. Clinical hepatitis, or inflammation of the liver, is not reportable in Canada, so to determine if an increase was occurring above historical levels, the baseline incidence in Canada was estimated. This article estimates the pre-existing baseline incidence of acute severe hepatitis of unknown origin in children in Canada using administrative databases. It further summarizes the outbreak investigation using information from the national case report forms.
UNASSIGNED: A committee with representatives from PHAC and provincial/territorial health partners was established to investigate current cases in Canada. A national probable case definition and case report form were developed, and intentionally created to be highly sensitive to capture all potential cases for etiological investigations. To estimate a nationally representative baseline incidence, hospitalization data were extracted from the Discharge Abstract Database and was combined with data from Québec from the Ministère de la Santé et des Services sociaux.
UNASSIGNED: Twenty-eight probable cases of acute severe hepatitis of unknown origin in children were reported between October 1, 2021, to September 23, 2022, by six provinces: British Columbia=1; Alberta=5; Saskatchewan=1; Manitoba=3; Ontario=14; and Québec=4. The estimated national baseline incidence was an average of 70 cases annually, or 5.8 cases per month.
UNASSIGNED: There was no apparent increase above the estimated historical baseline levels.
UNASSIGNED: A committee with representatives from PHAC and provincial/territorial health partners was established to investigate current cases in Canada. A national probable case definition and case report form were developed, and intentionally created to be highly sensitive to capture all potential cases for etiological investigations. To estimate a nationally representative baseline incidence, hospitalization data were extracted from the Discharge Abstract Database and was combined with data from Québec from the Ministère de la Santé et des Services sociaux.
UNASSIGNED: Twenty-eight probable cases of acute severe hepatitis of unknown origin in children were reported between October 1, 2021, to September 23, 2022, by six provinces: British Columbia=1; Alberta=5; Saskatchewan=1; Manitoba=3; Ontario=14; and Québec=4. The estimated national baseline incidence was an average of 70 cases annually, or 5.8 cases per month.
UNASSIGNED: There was no apparent increase above the estimated historical baseline levels.
摘要：
■2022年春季，英国和美国的一系列报告确定了儿童急性重症肝炎的发病率增加。加拿大公共卫生局（PHAC）与省/地区卫生伙伴合作，在加拿大进行调查。临床肝炎,或肝脏炎症，在加拿大不可报告，因此，为了确定是否出现高于历史水平的增长，对加拿大的基线发病率进行了估算.本文使用行政数据库估算了加拿大儿童中未知来源的急性重型肝炎的预先存在的基线发病率。它使用国家病例报告表中的信息进一步总结了疫情调查。
成立了一个由PHAC和省/地区卫生合作伙伴代表组成的委员会，以调查加拿大当前的病例。制定了国家可能病例定义和病例报告表，并故意创建高度敏感，以捕获所有潜在病例进行病因调查。估计具有全国代表性的基线发病率，我们从出院摘要数据库中提取住院数据,并将这些数据与魁北克省的社会服务部数据相结合.
■在2021年10月1日至2022年9月23日期间，六个省份报告了28例未知来源的急性重型肝炎的可能病例：不列颠哥伦比亚省=1;艾伯塔省=5;萨斯喀彻温省=1;马尼托巴省=3;安大略省=14;魁北克=4。估计的全国基线发病率是每年平均70例，或每月5.8例。
■没有明显高于估计的历史基线水平。
成立了一个由PHAC和省/地区卫生合作伙伴代表组成的委员会，以调查加拿大当前的病例。制定了国家可能病例定义和病例报告表，并故意创建高度敏感，以捕获所有潜在病例进行病因调查。估计具有全国代表性的基线发病率，我们从出院摘要数据库中提取住院数据,并将这些数据与魁北克省的社会服务部数据相结合.
■在2021年10月1日至2022年9月23日期间，六个省份报告了28例未知来源的急性重型肝炎的可能病例：不列颠哥伦比亚省=1;艾伯塔省=5;萨斯喀彻温省=1;马尼托巴省=3;安大略省=14;魁北克=4。估计的全国基线发病率是每年平均70例，或每月5.8例。
■没有明显高于估计的历史基线水平。
