PDF(Pubmed)
Abstract：
Stress-induced genomic changes in Candida albicans contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin C. albicans strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an intriguing question. Comparative genome analysis was carried out to uncover chromosomal aneuploidies and regions with loss of heterozygosity (LOH), two mechanisms that manage genome plasticity. We detected aneuploidy only in human isolates. Bird-derived isolates showed LOH in genes commonly associated with antifungal drug resistance similar to human isolates. Our study suggests that environmental fungicide usage might exert selective pressure on C. albicans infecting animals, thus contributing to the spread of potentially resistant strains between different hosts.
摘要：
白色念珠菌中应激诱导的基因组变化有助于该物种适应各种环境条件。动物来源的白色念珠菌菌株的基因组组成的变化在很大程度上是未探索的,并且驱动这些酵母进化的药物抗性或其他选择压力仍然是一个有趣的问题。进行了比较基因组分析，以揭示染色体非整倍体和杂合性缺失（LOH）的区域，管理基因组可塑性的两种机制。我们仅在人类分离物中检测到非整倍性。鸟源分离株在通常与抗真菌药物抗性相关的基因中显示LOH，与人类分离株相似。我们的研究表明，环境杀菌剂的使用可能会对感染动物的白色念珠菌施加选择性压力，从而有助于潜在抗性菌株在不同宿主之间的传播。
