关键词: Tall cell carcinoma with reversed polarity of the breast breast cancer clinicopathological features differential diagnosis histological characteristics

来  源:   DOI:10.3389/fonc.2024.1302196   PDF(Pubmed)

Abstract:
UNASSIGNED: The aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interventions.
UNASSIGNED: The clinicopathological characteristics and differential diagnosis of a patient with TCCRP were retrospectively analysed, and a systematic literature review was extracted from relevant published studies on PubMed.
UNASSIGNED: All patients included in the study were female, with a median age of 51 years. Microscopically, the tumour cells exhibited a solid papillary growth pattern with tall columnar morphology and reversed nuclear polarity. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. Different degrees of expression were observed for CK7, Calretinin, and S-100 markers; however, CK5/6 showed high expression levels.
UNASSIGNED: TCCRP is an uncommon invasive carcinoma subtype found in the breast. Its histological morphology resembles that of tall cell subtype papillary thyroid carcinoma. Accurate diagnosis requires the integration of histomorphological assessment along with immunohistochemistry and molecular genetics analysis.
摘要:
本报告的目的是全面调查临床病理特征,组织学特征,和鉴别诊断具有乳腺反极性的高细胞癌(TCCRP),以增强对该肿瘤的了解,以进行精确的治疗干预。
回顾性分析1例TCCRP患者的临床病理特征和鉴别诊断,并从PubMed上发表的相关研究中提取了系统的文献综述。
纳入研究的所有患者均为女性,平均年龄为51岁。微观上,肿瘤细胞表现出坚固的乳头状生长模式,具有高柱状形态和相反的核极性。免疫组织化学显示肿瘤为三阴性乳腺癌(ER阴性,PR,和HER-2),具有低Ki-67增殖指数。观察到CK7、Calretinin、和S-100标记;然而,CK5/6显示高表达水平。
TCCRP是一种罕见的乳腺浸润性癌亚型。其组织学形态类似于高细胞亚型甲状腺乳头状癌。准确的诊断需要结合组织形态学评估以及免疫组织化学和分子遗传学分析。
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