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Abstract：
UNASSIGNED: This study aims to compare the prognostic outcome of resection (RES) and microwave ablation (MWA) in different tumor burden score (TBS) cohorts.
UNASSIGNED: We retrospectively analyzed 479 patients with primary hepatocellular carcinoma (HCC) who underwent RES (n = 329) or MWA (n = 150) with curative intent at our institution. We assessed their overall survival (OS) and progression-free survival (PFS) using the Kaplan-Meier curve. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed to minimize selection and confounding biases. Multivariate Cox regression was used to define the association between surgical modalities and outcomes.
UNASSIGNED: Following PSM, in the TBS ≤3 cohort, the cumulative 1-, 3-, 5- year OS in the RES and MWA groups were 92.5% vs. 98.8%, 82.7% vs. 90.0%, and 82.7% vs. 83.2% (P = 0.366), respectively. The corresponding PFS rates in the RES and MWA groups were 82.7% vs. 88.0%, 63.6% vs. 68.3% and 55.2% vs. 56.3, respectively (P = 0.218). In the TBS >3 cohort, the cumulative 1-, 3-, 5- year OS between the RES and MWA groups were 92.5% vs. 95.0%, 82.8% vs. 73.2% and 76.3% vs. 55.1%, (P = 0.034), respectively. The corresponding PFS rates in the RES and MWA groups were 78.0% vs. 67.5%, 63.6% vs. 37.5% and 55.2% vs. 37.1%, respectively (P = 0.044). The IPTW analysis showed similar results as shown in PSM analysis. The multivariate Cox regression indicated that the type of surgical modality was not associated with a poorer prognostic outcome in the TBS ≤3 cohort, unlike in the TBS >3 cohort.
UNASSIGNED: TBS, as a discriminator, might help guide treatment decision-making for HCC within the Milan criteria.
UNASSIGNED: We retrospectively analyzed 479 patients with primary hepatocellular carcinoma (HCC) who underwent RES (n = 329) or MWA (n = 150) with curative intent at our institution. We assessed their overall survival (OS) and progression-free survival (PFS) using the Kaplan-Meier curve. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed to minimize selection and confounding biases. Multivariate Cox regression was used to define the association between surgical modalities and outcomes.
UNASSIGNED: Following PSM, in the TBS ≤3 cohort, the cumulative 1-, 3-, 5- year OS in the RES and MWA groups were 92.5% vs. 98.8%, 82.7% vs. 90.0%, and 82.7% vs. 83.2% (P = 0.366), respectively. The corresponding PFS rates in the RES and MWA groups were 82.7% vs. 88.0%, 63.6% vs. 68.3% and 55.2% vs. 56.3, respectively (P = 0.218). In the TBS >3 cohort, the cumulative 1-, 3-, 5- year OS between the RES and MWA groups were 92.5% vs. 95.0%, 82.8% vs. 73.2% and 76.3% vs. 55.1%, (P = 0.034), respectively. The corresponding PFS rates in the RES and MWA groups were 78.0% vs. 67.5%, 63.6% vs. 37.5% and 55.2% vs. 37.1%, respectively (P = 0.044). The IPTW analysis showed similar results as shown in PSM analysis. The multivariate Cox regression indicated that the type of surgical modality was not associated with a poorer prognostic outcome in the TBS ≤3 cohort, unlike in the TBS >3 cohort.
UNASSIGNED: TBS, as a discriminator, might help guide treatment decision-making for HCC within the Milan criteria.
摘要：
■本研究旨在比较不同肿瘤负荷评分（TBS）队列中切除（RES）和微波消融（MWA）的预后结果。
■我们回顾性分析了在我们机构接受RES（n=329）或MWA（n=150）治疗的479例原发性肝细胞癌（HCC）患者。我们使用Kaplan-Meier曲线评估了他们的总生存期（OS）和无进展生存期（PFS）。进行倾向评分匹配(PSM)和治疗加权的逆概率(IPTW)以最小化选择和混杂偏差。多变量Cox回归用于定义手术方式与结果之间的关联。
■在PSM之后，在TBS≤3队列中，累计1-，3-,RES和MWA组中的5年OS分别为92.5%和98.8%,82.7%vs.90.0%,和82.7%vs.83.2%(P=0.366)，分别。RES和MWA组相应的PFS率为82.7%。88.0%,63.6%与68.3%和55.2%与分别为56.3(P=0.218)。在TBS>3队列中，累计1-，3-,RES和MWA组之间的5年OS分别为92.5%和95.0%,82.8%与73.2%和76.3%vs.55.1%,（P=0.034），分别。RES和MWA组相应的PFS率为78.0%。67.5%,63.6%与37.5%和55.2%vs.37.1%,分别为(P=0.044)。IPTW分析显示出与PSM分析中所示相似的结果。多变量Cox回归表明，在TBS≤3的队列中，手术方式的类型与较差的预后结果无关。与TBS>3队列不同。
■TBS,作为一个鉴别器,可能有助于指导米兰标准内HCC的治疗决策。
■我们回顾性分析了在我们机构接受RES（n=329）或MWA（n=150）治疗的479例原发性肝细胞癌（HCC）患者。我们使用Kaplan-Meier曲线评估了他们的总生存期（OS）和无进展生存期（PFS）。进行倾向评分匹配(PSM)和治疗加权的逆概率(IPTW)以最小化选择和混杂偏差。多变量Cox回归用于定义手术方式与结果之间的关联。
■在PSM之后，在TBS≤3队列中，累计1-，3-,RES和MWA组中的5年OS分别为92.5%和98.8%,82.7%vs.90.0%,和82.7%vs.83.2%(P=0.366)，分别。RES和MWA组相应的PFS率为82.7%。88.0%,63.6%与68.3%和55.2%与分别为56.3(P=0.218)。在TBS>3队列中，累计1-，3-,RES和MWA组之间的5年OS分别为92.5%和95.0%,82.8%与73.2%和76.3%vs.55.1%,（P=0.034），分别。RES和MWA组相应的PFS率为78.0%。67.5%,63.6%与37.5%和55.2%vs.37.1%,分别为(P=0.044)。IPTW分析显示出与PSM分析中所示相似的结果。多变量Cox回归表明，在TBS≤3的队列中，手术方式的类型与较差的预后结果无关。与TBS>3队列不同。
■TBS,作为一个鉴别器,可能有助于指导米兰标准内HCC的治疗决策。
