PDF(Pubmed)
Abstract：
UNASSIGNED: In recent decades, there has been a notable increase in the morbidity and mortality rates linked to bacteremia and candidemia. This study aimed to investigate the clinical significance of inflammatory markers in assessing the disease severity in critically ill patients suffering from mixed-bloodstream infections (BSIs) due to Enterococcus spp. and Candida spp.
UNASSIGNED: In this retrospective research, patients diagnosed with BSIs who were admitted to the intensive care unit (ICU) during the period of January 2019 to December 2022 were analyzed. The patients were divided into two groups: a mixed-pathogen BSI group with both Enterococcus spp. and Candida spp., and a single-pathogen BSI group with only Enterococcus spp. The study examined the differences in inflammatory marker levels and disease severity, including Acute Physiology and Chronic Health Evaluation (APACHE) II scores, duration of ICU stay, and 30-day mortality, between the two groups. Furthermore, we sought to scrutinize the potential associations among these aforementioned parameters.
UNASSIGNED: The neutrophil-to-lymphocyte ratios (NLRs) and levels of plasma C-reactive protein (CRP), interleukin (IL)-6, IL-8, and tumor necrosis factor-α (TNF-α) in the mixed-pathogen BSI group were higher than those in the single-pathogen BSI group. Spearman\'s rank correlation analysis showed that NLRs and plasma CRP and IL-6 levels were positively correlated with disease severity in the mixed-pathogen BSI group. Further, the levels of plasma IL-8 and TNF-α were also positively correlated with ICU stay duration and 30-day mortality. In multivariate analysis, plasma CRP and IL-6 levels were independently associated with 30-day mortality.
UNASSIGNED: Mixed-pathogen BSIs caused by Enterococcus spp. and Candida spp. may give rise to increased NLRs and plasma CRP, IL-6, IL-8, and TNF-α levels in comparison to BSI caused by Enterococcus spp. only, thus leading to elevated disease severity in critically ill patients.
UNASSIGNED: In this retrospective research, patients diagnosed with BSIs who were admitted to the intensive care unit (ICU) during the period of January 2019 to December 2022 were analyzed. The patients were divided into two groups: a mixed-pathogen BSI group with both Enterococcus spp. and Candida spp., and a single-pathogen BSI group with only Enterococcus spp. The study examined the differences in inflammatory marker levels and disease severity, including Acute Physiology and Chronic Health Evaluation (APACHE) II scores, duration of ICU stay, and 30-day mortality, between the two groups. Furthermore, we sought to scrutinize the potential associations among these aforementioned parameters.
UNASSIGNED: The neutrophil-to-lymphocyte ratios (NLRs) and levels of plasma C-reactive protein (CRP), interleukin (IL)-6, IL-8, and tumor necrosis factor-α (TNF-α) in the mixed-pathogen BSI group were higher than those in the single-pathogen BSI group. Spearman\'s rank correlation analysis showed that NLRs and plasma CRP and IL-6 levels were positively correlated with disease severity in the mixed-pathogen BSI group. Further, the levels of plasma IL-8 and TNF-α were also positively correlated with ICU stay duration and 30-day mortality. In multivariate analysis, plasma CRP and IL-6 levels were independently associated with 30-day mortality.
UNASSIGNED: Mixed-pathogen BSIs caused by Enterococcus spp. and Candida spp. may give rise to increased NLRs and plasma CRP, IL-6, IL-8, and TNF-α levels in comparison to BSI caused by Enterococcus spp. only, thus leading to elevated disease severity in critically ill patients.
摘要：
■近几十年来，与菌血症和念珠菌菌血症相关的发病率和死亡率显著增加.这项研究旨在探讨炎症标志物在评估肠球菌属混合血流感染（BSIs）的危重患者疾病严重程度中的临床意义。和念珠菌属。
■在这项回顾性研究中，对2019年1月至2022年12月期间入住重症监护病房(ICU)的被诊断为BSIs的患者进行分析.患者分为两组：混合病原体BSI组，两种肠球菌属。和念珠菌属。,和仅具有肠球菌属的单病原体BSI组。该研究检查了炎症标志物水平和疾病严重程度的差异，包括急性生理学和慢性健康评估（APACHE）II评分，ICU住院时间,和30天死亡率，两组之间。此外，我们试图仔细检查上述参数之间的潜在关联。
■中性粒细胞与淋巴细胞比率（NLR）和血浆C反应蛋白（CRP）水平，混合病原体BSI组的白细胞介素（IL）-6，IL-8和肿瘤坏死因子-α（TNF-α）高于单病原体BSI组。Spearman等级相关分析显示,混合病原体BSI组NLR、血浆CRP和IL-6水平与疾病严重程度呈正相关。Further,血浆IL-8和TNF-α水平也与ICU住院时间和30天死亡率呈正相关.在多变量分析中，血浆CRP和IL-6水平与30天死亡率独立相关.
■由肠球菌属引起的混合病原体BSI。和念珠菌属。可能会导致NLR和血浆CRP增加，与肠球菌属引起的BSI相比，IL-6，IL-8和TNF-α水平。只有,从而导致危重患者疾病严重程度升高。
■在这项回顾性研究中，对2019年1月至2022年12月期间入住重症监护病房(ICU)的被诊断为BSIs的患者进行分析.患者分为两组：混合病原体BSI组，两种肠球菌属。和念珠菌属。,和仅具有肠球菌属的单病原体BSI组。该研究检查了炎症标志物水平和疾病严重程度的差异，包括急性生理学和慢性健康评估（APACHE）II评分，ICU住院时间,和30天死亡率，两组之间。此外，我们试图仔细检查上述参数之间的潜在关联。
■中性粒细胞与淋巴细胞比率（NLR）和血浆C反应蛋白（CRP）水平，混合病原体BSI组的白细胞介素（IL）-6，IL-8和肿瘤坏死因子-α（TNF-α）高于单病原体BSI组。Spearman等级相关分析显示,混合病原体BSI组NLR、血浆CRP和IL-6水平与疾病严重程度呈正相关。Further,血浆IL-8和TNF-α水平也与ICU住院时间和30天死亡率呈正相关.在多变量分析中，血浆CRP和IL-6水平与30天死亡率独立相关.
■由肠球菌属引起的混合病原体BSI。和念珠菌属。可能会导致NLR和血浆CRP增加，与肠球菌属引起的BSI相比，IL-6，IL-8和TNF-α水平。只有,从而导致危重患者疾病严重程度升高。
