PDF(Pubmed)
Abstract：
UNASSIGNED: Intraneural perineurioma is a rare, benign slow-growing lesion that usually involves a single main trunk nerve during childhood and young adulthood. The treatment of intraneural perineurioma is still a subject of controversy, especially in fast-growing children. To date, there was no systemic analysis of intraneural perineurioma in children.
UNASSIGNED: A case of Intraneural perineurioma affecting the left sciatic nerve with 2 years of follow-up was presented. A systematic review was performed on literature published before June 2023, focusing on intraneural perineurioma diagnosed at no older than 18 years old.
UNASSIGNED: A 9-year-old boy presented with progressive left foot-drop and abnormal gait for 2 years. The electromyography and magnetic resonance neurography study confirmed neuropathy involving the left sciatic nerves and its branches. Pathological investigation of the left sural nerve confirmed the diagnosis of intraneural perineurioma. The boy received physical therapy, and the disease was stable during the 2 years of follow-up. Fifty-seven childhood cases were identified in literature. Five patients with oral intraneural perineurioma underwent excision of the mass with good outcomes. In the other 52 patients with peripheral nerve involvement, 25 of them received surgical treatment, with different outcomes according to different operations. Out of 33 cases with precise lesion sizes, the length of the lesion in patients without nerve resection was significantly longer than that in patients with nerve resection (12.86 ± 7.44 cm vs 4.57 ± 4.5 cm. p < 0.05).
UNASSIGNED: Intraneural perineuriomas are rare benign tumors with slow progression. The options for surgery should be cautiously considered in childhood patients with long segmental peripheral nerve involvement.
UNASSIGNED: A case of Intraneural perineurioma affecting the left sciatic nerve with 2 years of follow-up was presented. A systematic review was performed on literature published before June 2023, focusing on intraneural perineurioma diagnosed at no older than 18 years old.
UNASSIGNED: A 9-year-old boy presented with progressive left foot-drop and abnormal gait for 2 years. The electromyography and magnetic resonance neurography study confirmed neuropathy involving the left sciatic nerves and its branches. Pathological investigation of the left sural nerve confirmed the diagnosis of intraneural perineurioma. The boy received physical therapy, and the disease was stable during the 2 years of follow-up. Fifty-seven childhood cases were identified in literature. Five patients with oral intraneural perineurioma underwent excision of the mass with good outcomes. In the other 52 patients with peripheral nerve involvement, 25 of them received surgical treatment, with different outcomes according to different operations. Out of 33 cases with precise lesion sizes, the length of the lesion in patients without nerve resection was significantly longer than that in patients with nerve resection (12.86 ± 7.44 cm vs 4.57 ± 4.5 cm. p < 0.05).
UNASSIGNED: Intraneural perineuriomas are rare benign tumors with slow progression. The options for surgery should be cautiously considered in childhood patients with long segmental peripheral nerve involvement.
摘要：
■神经内神经鞘瘤是一种罕见的，良性缓慢生长性病变，通常在童年和成年期间涉及单个主干神经。神经内神经鞘瘤的治疗仍然是一个有争议的话题,特别是在快速成长的孩子。迄今为止,没有对儿童神经内神经鞘瘤进行系统分析.
■一例累及左侧坐骨神经的神经内神经鞘瘤，随访2年。对2023年6月之前发表的文献进行了系统评价，重点是不超过18岁的神经内神经鞘瘤。
■一名9岁男孩出现进行性左脚下垂和步态异常2年。肌电图和磁共振神经造影研究证实了涉及左坐骨神经及其分支的神经病变。左腓肠神经的病理检查证实了神经内神经鞘瘤的诊断。这个男孩接受了物理治疗，在2年的随访期间病情稳定。文献中发现了57例儿童病例。5例口腔神经内神经鞘瘤患者接受了肿块切除术，效果良好。在其他52例周围神经受累的患者中，其中25人接受了手术治疗，根据不同的操作有不同的结果。33例病灶大小精确，未切除神经的患者的病变长度明显长于切除神经的患者（12.86±7.44cmvs4.57±4.5cm。p<0.05)。
■神经内神经鞘瘤是罕见且进展缓慢的良性肿瘤。对于长节段周围神经受累的儿童患者，应谨慎考虑手术选择。
■一例累及左侧坐骨神经的神经内神经鞘瘤，随访2年。对2023年6月之前发表的文献进行了系统评价，重点是不超过18岁的神经内神经鞘瘤。
■一名9岁男孩出现进行性左脚下垂和步态异常2年。肌电图和磁共振神经造影研究证实了涉及左坐骨神经及其分支的神经病变。左腓肠神经的病理检查证实了神经内神经鞘瘤的诊断。这个男孩接受了物理治疗，在2年的随访期间病情稳定。文献中发现了57例儿童病例。5例口腔神经内神经鞘瘤患者接受了肿块切除术，效果良好。在其他52例周围神经受累的患者中，其中25人接受了手术治疗，根据不同的操作有不同的结果。33例病灶大小精确，未切除神经的患者的病变长度明显长于切除神经的患者（12.86±7.44cmvs4.57±4.5cm。p<0.05)。
■神经内神经鞘瘤是罕见且进展缓慢的良性肿瘤。对于长节段周围神经受累的儿童患者，应谨慎考虑手术选择。
