PDF(Pubmed)
Abstract：
UNASSIGNED: Pain is a major challenge in performing ultrasound-guided percutaneous microwave ablation (PMWA) of uterine myomas. Inadequate analgesia by local anesthetics hinders the possibility of conducting PMWA of uterine myomas in the Ambulatory Surgery Center (ASC) of the Department of Ultrasound.
UNASSIGNED: The superior hypogastric plexus (SHP) forms a suitable target for pain relief through the blockade, as it contains nociceptive afferent fibers from pelvic organs such as the uterus, rectum, and bladder. Superior hypogastric plexus block (SHPB) has demonstrated promise as an alternative treatment option for alleviating pelvic pain, reducing opioid consumption, and improving quality of life. This study aims to evaluate the efficacy of ultrasound-guided SHPB combined with conscious sedation as an alternative anesthesia option for ambulatory patients receiving ultrasound-guided PMWA of uterine myomas.
UNASSIGNED: This randomized controlled trial (RCT) will be carried out at the Department of Ultrasound, The First Affiliated Hospital of Xiamen University. Women scheduled for ultrasound-guided PMWA of uterine myomas will be eligible. 86 patients will be recruited and randomly assigned to either the intervention or control groups in a 1:1 ratio. The intervention group will undergo ultrasound-guided superior hypogastric plexus block (SHPB) combined with conscious sedation, while the control group will receive local anesthesia combined with conscious sedation. The primary outcome is the success rate of anesthesia, secondary outcomes include vasoactive drug consumption, acetaminophen consumption, sleep quality, sonographer satisfaction score, patient satisfaction score, the detained time in hospital, and adverse events.
UNASSIGNED: This RCT represents the inaugural effort to specifically evaluate the safety and efficacy of ultrasound-guided SHPB combined with conscious sedation in patients undergoing ultrasound-guided PMWA of uterine myomas and will provide valuable evidence and insight into the analgesic management of this ambulatory surgery.
UNASSIGNED: This study has been approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University (Scientific Research Ethics Review 2023, No. 139). The results will be submitted for publication in peer-reviewed journals.
UNASSIGNED: The superior hypogastric plexus (SHP) forms a suitable target for pain relief through the blockade, as it contains nociceptive afferent fibers from pelvic organs such as the uterus, rectum, and bladder. Superior hypogastric plexus block (SHPB) has demonstrated promise as an alternative treatment option for alleviating pelvic pain, reducing opioid consumption, and improving quality of life. This study aims to evaluate the efficacy of ultrasound-guided SHPB combined with conscious sedation as an alternative anesthesia option for ambulatory patients receiving ultrasound-guided PMWA of uterine myomas.
UNASSIGNED: This randomized controlled trial (RCT) will be carried out at the Department of Ultrasound, The First Affiliated Hospital of Xiamen University. Women scheduled for ultrasound-guided PMWA of uterine myomas will be eligible. 86 patients will be recruited and randomly assigned to either the intervention or control groups in a 1:1 ratio. The intervention group will undergo ultrasound-guided superior hypogastric plexus block (SHPB) combined with conscious sedation, while the control group will receive local anesthesia combined with conscious sedation. The primary outcome is the success rate of anesthesia, secondary outcomes include vasoactive drug consumption, acetaminophen consumption, sleep quality, sonographer satisfaction score, patient satisfaction score, the detained time in hospital, and adverse events.
UNASSIGNED: This RCT represents the inaugural effort to specifically evaluate the safety and efficacy of ultrasound-guided SHPB combined with conscious sedation in patients undergoing ultrasound-guided PMWA of uterine myomas and will provide valuable evidence and insight into the analgesic management of this ambulatory surgery.
UNASSIGNED: This study has been approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University (Scientific Research Ethics Review 2023, No. 139). The results will be submitted for publication in peer-reviewed journals.
摘要：
疼痛是子宫肌瘤超声引导经皮微波消融（PMWA）的主要挑战。局部麻醉药的镇痛不足阻碍了在超声科门诊手术中心（ASC）进行子宫肌瘤PMWA的可能性。
■上腹下丛（SHP）通过阻滞形成了缓解疼痛的合适目标，因为它含有来自盆腔器官如子宫的伤害性传入纤维，直肠,和膀胱。高级腹下神经丛阻滞（SHPB）已被证明是减轻骨盆疼痛的替代治疗选择。减少阿片类药物的消费，提高生活质量。这项研究旨在评估超声引导下的SHPB联合清醒镇静作为接受超声引导下的子宫肌瘤PMWA的非卧床患者的替代麻醉选择的有效性。
■这项随机对照试验（RCT）将在超声科进行，厦门大学附属第一医院.计划接受超声引导的子宫肌瘤PMWA的妇女将有资格。将招募86名患者，并以1：1的比例随机分配到干预组或对照组。干预组行超声引导下上腹下丛神经阻滞(SHPB)联合清醒镇静,对照组给予局部麻醉联合清醒镇静。主要结果是麻醉的成功率，次要结果包括血管活性药物消耗，对乙酰氨基酚的消费，睡眠质量,超声医师满意度评分,患者满意度评分,在医院的拘留时间，和不良事件。
■该RCT代表了首次努力，专门评估超声引导下SHPB联合清醒镇静在子宫肌瘤超声引导下PMWA患者中的安全性和有效性，并将提供有价值的证据和见解。门诊手术的镇痛管理。
■本研究已获厦门大学附属第一医院伦理委员会批准(科学研究伦理审查2023号139).结果将提交在同行评审的期刊上发表。
■上腹下丛（SHP）通过阻滞形成了缓解疼痛的合适目标，因为它含有来自盆腔器官如子宫的伤害性传入纤维，直肠,和膀胱。高级腹下神经丛阻滞（SHPB）已被证明是减轻骨盆疼痛的替代治疗选择。减少阿片类药物的消费，提高生活质量。这项研究旨在评估超声引导下的SHPB联合清醒镇静作为接受超声引导下的子宫肌瘤PMWA的非卧床患者的替代麻醉选择的有效性。
■这项随机对照试验（RCT）将在超声科进行，厦门大学附属第一医院.计划接受超声引导的子宫肌瘤PMWA的妇女将有资格。将招募86名患者，并以1：1的比例随机分配到干预组或对照组。干预组行超声引导下上腹下丛神经阻滞(SHPB)联合清醒镇静,对照组给予局部麻醉联合清醒镇静。主要结果是麻醉的成功率，次要结果包括血管活性药物消耗，对乙酰氨基酚的消费，睡眠质量,超声医师满意度评分,患者满意度评分,在医院的拘留时间，和不良事件。
■该RCT代表了首次努力，专门评估超声引导下SHPB联合清醒镇静在子宫肌瘤超声引导下PMWA患者中的安全性和有效性，并将提供有价值的证据和见解。门诊手术的镇痛管理。
■本研究已获厦门大学附属第一医院伦理委员会批准(科学研究伦理审查2023号139).结果将提交在同行评审的期刊上发表。
