Abstract：
BACKGROUND: Frontal fibrosing alopecia (FFA) is characterized by scarring alopecia of the frontotemporal scalp and facial papules. Isotretinoin is a vitamin A-derived retinoid discovered in 1955 and approved for treating nodulocystic acne. This drug can also affect facial papules and frontotemporal hair loss in patients with FFA. In this article, we conducted a review of the available studies investigating the use of oral isotretinoin for FFA treatment. Our study provides insights into the efficacy and safety of isotretinoin as a potential treatment option for FFA and highlights areas for future research.
METHODS: In this study, we aimed to investigate the potential advantages and disadvantages of isotretinoin as a treatment for FFA. To identify all relevant articles, we developed a comprehensive search strategy and conducted a thorough search of three major databases: PubMed, Embase, and Science Direct. We retrieved a total of 82 articles from the search results. Two independent reviewers then screened each of the 82 articles based on our inclusion and exclusion criteria, resulting in the identification of 15 articles that were deemed relevant to our study.
RESULTS: Across the 15 articles, 232 patients who suffered from FFA were involved. Nearly 90% of patients experienced a significant reduction of symptoms after receiving oral isotretinoin at 10-40 mg daily. We conclude that isotretinoin can positively affect facial papules and help suppress hair loss.
METHODS: In this study, we aimed to investigate the potential advantages and disadvantages of isotretinoin as a treatment for FFA. To identify all relevant articles, we developed a comprehensive search strategy and conducted a thorough search of three major databases: PubMed, Embase, and Science Direct. We retrieved a total of 82 articles from the search results. Two independent reviewers then screened each of the 82 articles based on our inclusion and exclusion criteria, resulting in the identification of 15 articles that were deemed relevant to our study.
RESULTS: Across the 15 articles, 232 patients who suffered from FFA were involved. Nearly 90% of patients experienced a significant reduction of symptoms after receiving oral isotretinoin at 10-40 mg daily. We conclude that isotretinoin can positively affect facial papules and help suppress hair loss.
摘要：
背景：额叶纤维性脱发（FFA）的特征是额颞叶头皮和面部丘疹的瘢痕性脱发。异维A酸是一种维生素A衍生的类维生素A，于1955年发现，并被批准用于治疗囊性痤疮。该药物还可以影响FFA患者的面部丘疹和额颞叶脱发。在这篇文章中,我们对现有研究进行了综述,这些研究调查了口服异维甲酸用于FFA治疗的用途.我们的研究提供了对异维A酸作为FFA的潜在治疗选择的有效性和安全性的见解，并强调了未来研究的领域。
方法：在本研究中，我们旨在探讨异维A酸作为FFA治疗的潜在优势和劣势.为了识别所有相关文章，我们制定了全面的搜索策略，并对三个主要数据库进行了彻底的搜索：PubMed，Embase,科学直接。从搜索结果中，我们共检索到82篇文章。然后，两名独立审稿人根据我们的纳入和排除标准对82篇文章中的每一篇进行了筛选，结果确定了15篇被认为与我们的研究相关的文章。
结果：在15篇文章中，232名患有FFA的患者参与其中。近90％的患者在接受每日10-40mg的口服异维A酸后症状显着减轻。我们得出的结论是，异维A酸可以积极影响面部丘疹并有助于抑制脱发。
方法：在本研究中，我们旨在探讨异维A酸作为FFA治疗的潜在优势和劣势.为了识别所有相关文章，我们制定了全面的搜索策略，并对三个主要数据库进行了彻底的搜索：PubMed，Embase,科学直接。从搜索结果中，我们共检索到82篇文章。然后，两名独立审稿人根据我们的纳入和排除标准对82篇文章中的每一篇进行了筛选，结果确定了15篇被认为与我们的研究相关的文章。
结果：在15篇文章中，232名患有FFA的患者参与其中。近90％的患者在接受每日10-40mg的口服异维A酸后症状显着减轻。我们得出的结论是，异维A酸可以积极影响面部丘疹并有助于抑制脱发。
