PDF(Pubmed)
Abstract：
The response of the host to plaque can be affected by systemic diseases like diabetes, hormonal changes, or immunological deficits, which can hasten the progression and severity of periodontitis. This study aimed to compare the activity of salivary matrix metalloproteinase-8 (MMP-8) in patients with moderate to severe generalized chronic generalized periodontitis between healthy individuals and those with type 2 diabetes who were referred to the Tabriz School of Dentistry.
For this cross-sectional study, 90 patients were randomly divided into three groups based on inclusion and exclusion criteria: patients with chronic generalized periodontitis with diabetes, patients with generalized chronic periodontal disease with normal blood glucose, and a control group of 30 healthy individuals. Participants were instructed not to brush their teeth for 12 h and not to eat or drink for 90 min before saliva sampling. Saliva samples were immediately stored at -80°C and analyzed using an ELISA test.
The results showed that there was a significant difference in salivary MMP-8 levels among the three groups. Patients with periodontitis and diabetes had the highest levels of salivary MMP-8, while the control group had the lowest levels. This indicates that chronic generalized periodontitis is strongly associated with the activity level of salivary MMP-8, and elevated levels of MMP-8 in diabetic patients demonstrate the impact of diabetes on periodontal disease.
This study highlights the importance of monitoring salivary MMP-8 levels in patients with periodontitis, especially those with diabetes. It also emphasizes the need for proper management of systemic diseases to prevent or slow down the progression of periodontal disease.
For this cross-sectional study, 90 patients were randomly divided into three groups based on inclusion and exclusion criteria: patients with chronic generalized periodontitis with diabetes, patients with generalized chronic periodontal disease with normal blood glucose, and a control group of 30 healthy individuals. Participants were instructed not to brush their teeth for 12 h and not to eat or drink for 90 min before saliva sampling. Saliva samples were immediately stored at -80°C and analyzed using an ELISA test.
The results showed that there was a significant difference in salivary MMP-8 levels among the three groups. Patients with periodontitis and diabetes had the highest levels of salivary MMP-8, while the control group had the lowest levels. This indicates that chronic generalized periodontitis is strongly associated with the activity level of salivary MMP-8, and elevated levels of MMP-8 in diabetic patients demonstrate the impact of diabetes on periodontal disease.
This study highlights the importance of monitoring salivary MMP-8 levels in patients with periodontitis, especially those with diabetes. It also emphasizes the need for proper management of systemic diseases to prevent or slow down the progression of periodontal disease.
摘要：
目的：宿主对斑块的反应可能受到系统性疾病如糖尿病的影响，荷尔蒙的变化,或者免疫缺陷，可以加速牙周炎的进展和严重程度。这项研究旨在比较健康个体和转介给大不里士牙科学院的2型糖尿病患者中中度至重度广泛性慢性广泛性牙周炎患者唾液基质金属蛋白酶8（MMP-8）的活性。
方法：对于这项横断面研究，根据纳入和排除标准,将90例患者随机分为3组:慢性广泛性牙周炎合并糖尿病,血糖正常的广泛性慢性牙周病患者，和30名健康个体的对照组。要求参与者在唾液采样前12小时内不要刷牙，90分钟内不要进食或饮水。将唾液样品立即储存在-80°C并使用ELISA测试进行分析。
结果：结果显示，三组之间唾液MMP-8水平存在显着差异。牙周炎和糖尿病患者的唾液MMP-8水平最高，而对照组的水平最低。这表明慢性广泛性牙周炎与唾液MMP-8的活性水平密切相关，糖尿病患者中MMP-8水平的升高表明糖尿病对牙周病的影响。
结论：这项研究强调了监测牙周炎患者唾液MMP-8水平的重要性。尤其是糖尿病患者。它还强调需要适当管理全身性疾病以预防或减缓牙周病的进展。
方法：对于这项横断面研究，根据纳入和排除标准,将90例患者随机分为3组:慢性广泛性牙周炎合并糖尿病,血糖正常的广泛性慢性牙周病患者，和30名健康个体的对照组。要求参与者在唾液采样前12小时内不要刷牙，90分钟内不要进食或饮水。将唾液样品立即储存在-80°C并使用ELISA测试进行分析。
结果：结果显示，三组之间唾液MMP-8水平存在显着差异。牙周炎和糖尿病患者的唾液MMP-8水平最高，而对照组的水平最低。这表明慢性广泛性牙周炎与唾液MMP-8的活性水平密切相关，糖尿病患者中MMP-8水平的升高表明糖尿病对牙周病的影响。
结论：这项研究强调了监测牙周炎患者唾液MMP-8水平的重要性。尤其是糖尿病患者。它还强调需要适当管理全身性疾病以预防或减缓牙周病的进展。
