Abstract：
Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal of these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments, often causing patient discomfort due to side effects, have led researchers to explore innovative, targeted cancer cell therapies. Thus, biopolymer-based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, the author discuss the role of biopolymer-based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer-based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer-based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications.
摘要：
癌症是全球死亡的主要原因，化疗是一种关键的治疗方法，单独或与其他疗法联合使用。这些疗法的主要目标是抑制癌细胞的生长，同时尽量减少对健康分裂细胞的伤害。常规治疗因其副作用而受到阻碍，经常给患者带来严重的不适。研究人员一直在探索选择性靶向癌细胞的创新方法。在这种情况下，基于生物聚合物的气凝胶作为创新平台出现，展示对不同刺激做出智能反应的独特属性，包括温度,pH值变化,磁场,和氧化还原电位。这种反应能够精确控制抗癌药物的释放，提高治疗效果。这些气凝胶的意义在于它们能够提供具有增加功效的靶向药物递送。生物相容性，和高药物有效载荷。在这次全面审查中，我们讨论了基于生物聚合物的气凝胶作为抗癌药物递送中新兴的功能化平台的作用。该综述讨论了基于生物聚合物的气凝胶的独特特性，显示了它们在响应包括温度在内的不同刺激时的智能行为。pH值,磁性和氧化还原电位来控制抗癌药物的释放。最后,这篇综述讨论了基于生物聚合物的气凝胶在递送不同抗癌药物中的应用，并讨论了这些平台在基因递送应用中的潜力。本文受版权保护。保留所有权利。
