Abstract：
The primary objective of this study was to identify the predominant organisms associated with ventilator-associated pneumonia (VAP) in Japan. Studies on VAP conducted in Japan were systematically reviewed, and seven studies with a total of 374 cases were included. The detection rate of each bacterium and multidrug-resistant (MDR) pathogen was analyzed using the inverse variance method. Pseudomonas aeruginosa was identified as the predominant pathogen in 29.2 % of cases, followed by methicillin-resistant Staphylococcus aureus (MRSA) (12.0 %), and Klebsiella spp. (9.5 %). An integrated analysis revealed a detection rate of 57.8 % (95 % confidence interval: 48.7%-66.8 %) for MDR pathogens. This review highlights P. aeruginosa and MRSA as the predominant VAP-associated organisms in Japan, with a significant prevalence of MDR pathogens. This analysis provides valuable insights based on the regional distribution of bacteria detected in VAP, which is critical for selecting appropriate empirical therapy.
摘要：
这项研究的主要目的是确定与日本呼吸机相关性肺炎（VAP）相关的主要生物。系统回顾了在日本进行的VAP研究，共纳入7项研究，共374例。使用逆方差法分析每种细菌和多药耐药（MDR）病原体的检出率。在29.2%的病例中，铜绿假单胞菌被确定为主要病原体，其次是耐甲氧西林金黄色葡萄球菌（MRSA）（12.0%），和克雷伯菌属。(9.5%)。综合分析显示MDR病原体的检出率为57.8％（95％置信区间：48.7％-66.8％）。这篇综述强调了铜绿假单胞菌和MRSA是日本主要的VAP相关生物。具有显著的MDR病原体流行率。基于VAP中检测到的细菌的区域分布，该分析提供了有价值的见解，这对于选择合适的经验疗法至关重要。
