Abstract：
UNASSIGNED: NF2-schwannomatosis (NF2) is an autosomal dominant disorder prone to hearing loss. Auditory brainstem implants (ABIs) offer a promising solution for hearing rehabilitation in NF2.
UNASSIGNED: To synthesize existing literature on ABI implantation in NF2, focusing on audiological outcomes and ABI-related complications.
UNASSIGNED: The systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022362155). Relevant studies were identified by searching PubMed, EMBASE, CENTRAL, CMB, and CNKI from inception to August 2023. Data on environmental sound discrimination, open-set discrimination, closed-set discrimination, and ABI-related complications were extracted and subjected to meta-analysis. Publication bias was evaluated using funnel plots and Egger\'s test.
UNASSIGNED: Thirty-three studies were included. The pooled estimate was 58% (95% CI 49-66%) for environmental sound discrimination and 55% (95% CI 40-69%) for closed-set discrimination. Regarding open-set discrimination, the pooled estimates were 30% (95% CI 19-42%) for sound only, 46% (95% CI 37-54%) for lip-reading only, and 63% (95% CI 55-70%) for sound plus lip-reading. The pooled occurrence of ABI-related complications was 33% (95% CI 15-52%).
UNASSIGNED: This meta-analysis underscores the effectiveness and safety of ABIs in NF2, providing valuable insights for evidence-based decision-making and hearing rehabilitation strategies.
UNASSIGNED: To synthesize existing literature on ABI implantation in NF2, focusing on audiological outcomes and ABI-related complications.
UNASSIGNED: The systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022362155). Relevant studies were identified by searching PubMed, EMBASE, CENTRAL, CMB, and CNKI from inception to August 2023. Data on environmental sound discrimination, open-set discrimination, closed-set discrimination, and ABI-related complications were extracted and subjected to meta-analysis. Publication bias was evaluated using funnel plots and Egger\'s test.
UNASSIGNED: Thirty-three studies were included. The pooled estimate was 58% (95% CI 49-66%) for environmental sound discrimination and 55% (95% CI 40-69%) for closed-set discrimination. Regarding open-set discrimination, the pooled estimates were 30% (95% CI 19-42%) for sound only, 46% (95% CI 37-54%) for lip-reading only, and 63% (95% CI 55-70%) for sound plus lip-reading. The pooled occurrence of ABI-related complications was 33% (95% CI 15-52%).
UNASSIGNED: This meta-analysis underscores the effectiveness and safety of ABIs in NF2, providing valuable insights for evidence-based decision-making and hearing rehabilitation strategies.
摘要：
■NF2-神经鞘瘤病（NF2）是一种常染色体显性遗传的听力损失。听觉脑干植入物（ABIs）为NF2中的听力康复提供了有希望的解决方案。
■综合有关NF2中ABI植入的现有文献，重点是听力学结果和ABI相关并发症。
■系统评价遵循PRISMA指南，并在PROSPERO数据库（CRD42022362155）中注册。相关研究是通过搜索PubMed确定的，EMBASE,中部,CMB,和CNKI从成立到2023年8月。关于环境健全歧视的数据，开放式歧视，封闭式歧视，提取ABI相关并发症并进行荟萃分析.使用漏斗图和Egger检验评估发表偏倚。
■纳入了33项研究。对于环境声音辨别，汇总估计为58％（95％CI49-66％），对于闭集辨别，汇总估计为55％（95％CI40-69％）。关于开放式歧视，仅声音的汇总估计值为30%(95%CI19-42%)，46%（95%CI37-54%）仅用于唇读，声音加唇读占63%（95%CI55-70%）。ABI相关并发症的合并发生率为33%（95%CI15-52%）。
■这项荟萃分析强调了NF2中ABI的有效性和安全性，为基于证据的决策和听力康复策略提供了有价值的见解。
■综合有关NF2中ABI植入的现有文献，重点是听力学结果和ABI相关并发症。
■系统评价遵循PRISMA指南，并在PROSPERO数据库（CRD42022362155）中注册。相关研究是通过搜索PubMed确定的，EMBASE,中部,CMB,和CNKI从成立到2023年8月。关于环境健全歧视的数据，开放式歧视，封闭式歧视，提取ABI相关并发症并进行荟萃分析.使用漏斗图和Egger检验评估发表偏倚。
■纳入了33项研究。对于环境声音辨别，汇总估计为58％（95％CI49-66％），对于闭集辨别，汇总估计为55％（95％CI40-69％）。关于开放式歧视，仅声音的汇总估计值为30%(95%CI19-42%)，46%（95%CI37-54%）仅用于唇读，声音加唇读占63%（95%CI55-70%）。ABI相关并发症的合并发生率为33%（95%CI15-52%）。
■这项荟萃分析强调了NF2中ABI的有效性和安全性，为基于证据的决策和听力康复策略提供了有价值的见解。
