PDF(Pubmed)
Abstract：
The tumor microenvironment is composed of tumor cells, stromal cells and leukocytes, including innate and adaptive immune cells, and represents an ecological niche that regulates tumor development and progression. In general, inflammatory cells are considered to contribute to tumor progression through various mechanisms, including the formation of an immunosuppressive microenvironment. Macrophages and neutrophils are important components of the tumor microenvironment and can act as a double-edged sword, promoting or inhibiting the development of the tumor. Targeting of the immune system is emerging as an important therapeutic strategy for cancer patients. However, the efficacy of the various immunotherapies available is still limited. Given the crucial importance of the crosstalk between macrophages and neutrophils and other immune cells in the formation of the anti-tumor immune response, targeting these interactions may represent a promising therapeutic approach against cancer. Here we will review the current knowledge of the role played by macrophages and neutrophils in cancer, focusing on their interaction with other immune cells.
摘要：
肿瘤微环境由肿瘤细胞组成,基质细胞和白细胞，包括先天和适应性免疫细胞，代表了一个调节肿瘤发展和进展的生态位。总的来说,炎症细胞被认为通过各种机制促进肿瘤进展，包括免疫抑制微环境的形成。巨噬细胞和中性粒细胞是肿瘤微环境的重要组成部分,促进或抑制肿瘤的发展。靶向免疫系统正在成为癌症患者的重要治疗策略。然而,可用的各种免疫疗法的功效仍然有限。鉴于巨噬细胞与中性粒细胞和其他免疫细胞之间的串扰在抗肿瘤免疫反应的形成中至关重要，靶向这些相互作用可能代表了一种有希望的癌症治疗方法。在这里，我们将回顾巨噬细胞和中性粒细胞在癌症中所起的作用的最新知识，专注于它们与其他免疫细胞的相互作用。
