PDF(Pubmed)
Abstract：
UNASSIGNED: Previous research has shown that lower lactate dehydrogenase (LDH) concentrations in cerebrospinal fluid (CSF) are associated with longer prodromal symptoms in first-episode psychosis (FEP). We aimed to study whether there is a relationship between the duration of untreated psychosis (DUP) and LDH and other CSF biomarkers in FEP and whether stressful life events moderate this association.
UNASSIGNED: Ninety-five inpatients with FEP and with less than 6 weeks of antipsychotic treatment were included in the study. All participants were informed about the nature of the study, which was approved by the local ethics committee, and signed an informed consent form. A lumbar puncture was performed at index admission (baseline) to measure CSF parameters (glucose, total protein, LDH). The DUP was assessed with the Quick Psychosis Onset and Prodromal Symptoms Inventory (Q-POPSI). Stressful life events (SLEs) in the previous 6 months were assessed with the List of Threatening Experiences. We dichotomized the SLE variable into having experienced at least one SLE or no experience of SLEs. Statistical analyses were performed with SPSS v. 25.0. Total protein and LDH concentrations were natural log transformed (ln) to reduce skewness. Multiple linear regression analyses were conducted to explore the association between the DUP and CSF parameters (considered the dependent variable). Age, sex, DUP and SLEs were considered independent variables. We tested the DUP by SLE interaction. Significant interactions were included in the final model. The threshold for significance was set at p<0.05.
UNASSIGNED: Fifty-four FEP patients (56.8%) reported an SLE in the previous 6 months. There were no significant differences in the DUP between patients with or without SLEs. There were no significant differences in CSF biomarkers between the SLE groups. In the multiple linear regression analyses, we found a significant DUP by SLE interaction effect on CSF LDH concentrations (standardized beta= -0.320, t= -2.084, p= 0.040). In patients with SLEs, a shorter DUP was associated with higher CSF LDH concentrations and vice versa. No significant associations were found between the DUP or SLEs and other CSF biomarkers (glucose, total proteins).
UNASSIGNED: Our study suggests that psychosocial stress moderates the relationship between the onset of psychosis and CSF biomarkers related to bioenergetic systems.
UNASSIGNED: Ninety-five inpatients with FEP and with less than 6 weeks of antipsychotic treatment were included in the study. All participants were informed about the nature of the study, which was approved by the local ethics committee, and signed an informed consent form. A lumbar puncture was performed at index admission (baseline) to measure CSF parameters (glucose, total protein, LDH). The DUP was assessed with the Quick Psychosis Onset and Prodromal Symptoms Inventory (Q-POPSI). Stressful life events (SLEs) in the previous 6 months were assessed with the List of Threatening Experiences. We dichotomized the SLE variable into having experienced at least one SLE or no experience of SLEs. Statistical analyses were performed with SPSS v. 25.0. Total protein and LDH concentrations were natural log transformed (ln) to reduce skewness. Multiple linear regression analyses were conducted to explore the association between the DUP and CSF parameters (considered the dependent variable). Age, sex, DUP and SLEs were considered independent variables. We tested the DUP by SLE interaction. Significant interactions were included in the final model. The threshold for significance was set at p<0.05.
UNASSIGNED: Fifty-four FEP patients (56.8%) reported an SLE in the previous 6 months. There were no significant differences in the DUP between patients with or without SLEs. There were no significant differences in CSF biomarkers between the SLE groups. In the multiple linear regression analyses, we found a significant DUP by SLE interaction effect on CSF LDH concentrations (standardized beta= -0.320, t= -2.084, p= 0.040). In patients with SLEs, a shorter DUP was associated with higher CSF LDH concentrations and vice versa. No significant associations were found between the DUP or SLEs and other CSF biomarkers (glucose, total proteins).
UNASSIGNED: Our study suggests that psychosocial stress moderates the relationship between the onset of psychosis and CSF biomarkers related to bioenergetic systems.
摘要：
■先前的研究表明，脑脊液（CSF）中较低的乳酸脱氢酶（LDH）浓度与首发精神病（FEP）的前驱症状较长有关。我们旨在研究未治疗的精神病（DUP）的持续时间与FEP中LDH和其他CSF生物标志物之间是否存在关系，以及压力性生活事件是否可以缓解这种关联。
■95例FEP患者和抗精神病药物治疗少于6周的患者被纳入研究。所有参与者都被告知研究的性质，得到了当地道德委员会的批准，并签署了知情同意书。首次入院时（基线）进行腰椎穿刺以测量CSF参数（葡萄糖，总蛋白质，LDH）。使用快速精神病发作和前驱症状清单（Q-POPSI）评估DUP。通过威胁经历列表评估了过去6个月的压力生活事件（SLE）。我们将SLE变量分为至少经历过一次SLE或没有SLE的经历。用SPSSv.25.0进行统计分析。总蛋白和LDH浓度被自然对数转化(ln)以减少偏度。进行多元线性回归分析以探索DUP和CSF参数(考虑因变量)之间的关联。年龄,性别,DUP和SLE被认为是独立变量。我们通过SLE相互作用测试了DUP。最终模型中包括了显著的相互作用。显著性阈值设定为p<0.05。
■54名FEP患者（56.8％）在过去6个月中报告了SLE。有或没有SLE的患者之间的DUP没有显着差异。SLE组之间的CSF生物标志物没有显着差异。在多元线性回归分析中，我们发现SLE交互作用对CSFLDH浓度有显著的DUP效应(标准化β=-0.320,t=-2.084,p=0.040).在SLE患者中，较短的DUP与较高的CSFLDH浓度相关,反之亦然.DUP或SLE与其他CSF生物标志物(葡萄糖，总蛋白质)。
■我们的研究表明，心理社会压力调节了精神病发作与与生物能量系统相关的CSF生物标志物之间的关系。
■95例FEP患者和抗精神病药物治疗少于6周的患者被纳入研究。所有参与者都被告知研究的性质，得到了当地道德委员会的批准，并签署了知情同意书。首次入院时（基线）进行腰椎穿刺以测量CSF参数（葡萄糖，总蛋白质，LDH）。使用快速精神病发作和前驱症状清单（Q-POPSI）评估DUP。通过威胁经历列表评估了过去6个月的压力生活事件（SLE）。我们将SLE变量分为至少经历过一次SLE或没有SLE的经历。用SPSSv.25.0进行统计分析。总蛋白和LDH浓度被自然对数转化(ln)以减少偏度。进行多元线性回归分析以探索DUP和CSF参数(考虑因变量)之间的关联。年龄,性别,DUP和SLE被认为是独立变量。我们通过SLE相互作用测试了DUP。最终模型中包括了显著的相互作用。显著性阈值设定为p<0.05。
■54名FEP患者（56.8％）在过去6个月中报告了SLE。有或没有SLE的患者之间的DUP没有显着差异。SLE组之间的CSF生物标志物没有显着差异。在多元线性回归分析中，我们发现SLE交互作用对CSFLDH浓度有显著的DUP效应(标准化β=-0.320,t=-2.084,p=0.040).在SLE患者中，较短的DUP与较高的CSFLDH浓度相关,反之亦然.DUP或SLE与其他CSF生物标志物(葡萄糖，总蛋白质)。
■我们的研究表明，心理社会压力调节了精神病发作与与生物能量系统相关的CSF生物标志物之间的关系。
