PDF(Pubmed)
Abstract：
Background Hyaluronic acid fillers can be manufactured using various processes. They have multiple properties, including their concentration, degree of modification, and rheological data. Cohesion is one such property to evaluate gel integrity; however, there is no standardized method for calculating this parameter. This study aimed to evaluate different tests for calculating hyaluronic acid cohesion and discuss the importance of hyaluronic acid cohesion as a consideration when selecting fillers. Methods The cohesion levels of five different hyaluronic acid fillers with different rheological properties were evaluated and compared using the drop weight, compression, tack, and dispersion time tests. Results The cohesion tests yielded different results in the samples. Samples 2 and 4 showed approximately two times the number of droplets when compared with Sample 5 in drop weight test. Samples 1, 2, 3, and 4 were superior to Sample 5 in tack test. Samples 1, 2, and 3 showed cohesive appearances at 95 seconds in most cases in dispersion test. Rheological test results did not reflect the measures of cohesion. Conclusion Although there are no definite standardized tests to evaluate the cohesion of hyaluronic acid fillers, our proposed tests showed similar results for different hyaluronic acid filler products. Further studies are needed to evaluate the cohesion of hyaluronic acid fillers and determine the clinical use of this distinguishing characteristic for clinicians selecting the product of choice. Level of evidence statement: These data are Level IV evidence.
摘要：
背景技术透明质酸填充剂可以使用各种方法制造。他们有多个属性，包括他们的浓度，改性程度,和流变学数据。粘结性是评估凝胶完整性的一种特性；然而，没有计算该参数的标准化方法。本研究旨在评估计算透明质酸内聚力的不同测试，并讨论选择填充剂时考虑透明质酸内聚力的重要性。方法采用落锤对5种不同流变特性的透明质酸填充剂的内聚力进行评价和比较,压缩，大头钉,和分散时间测试。结果内聚力测试在样品中产生不同的结果。当在液滴重量测试中与样品5相比时,样品2和4显示大约两倍的液滴数量。样品1、2、3和4在粘性测试方面优于样品5。在大多数情况下,样品1、2和3在分散试验中在95秒时显示出内聚外观。流变测试结果没有反映内聚力的测量。结论虽然没有明确的标准化试验来评价透明质酸填充剂的内聚力,我们提出的测试显示相似的结果，不同的透明质酸填充产品。需要进一步的研究来评估透明质酸填充剂的内聚力，并确定这种区别特征的临床用途，以供临床医生选择所选产品。证据水平声明：这些数据是IV级证据。
