PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to assess the course of changes in choroidal morphology after immersion of the foot in warm water at 40°C using enhanced depth imaging optical coherence tomography (EDI-OCT).
METHODS: Forty-three right eyes of 43 healthy participants were included. Changes in choroidal morphology were determined using EDI-OCT to evaluate subfoveal choroidal thickness (SCT). Systolic, diastolic, and mean blood pressures (SBP, DBP, and MBP, respectively) were also measured to determine systemic circulatory dynamics at baseline, immediately after immersion (0 min), and 10, 20, and 30 min after immersion.
RESULTS: Immediately after immersion, SBP, DBP, and MBP were significantly declined versus baseline. In contrast, the SCT was significantly increased after warm water immersion. However, all these parameters did not change significantly compared to the baseline within 30 min.
CONCLUSIONS: In the normal eye, parasympathetic nerve activity induced by warming stimuli increases choroidal morphology in response to a decrease in systemic circulatory activity, which normalizes within 30 min. The findings of this study may provide basic data for the prevention and treatment of various choroidal diseases in which sympathetic hyperactivity is involved in the pathogenesis.
METHODS: Forty-three right eyes of 43 healthy participants were included. Changes in choroidal morphology were determined using EDI-OCT to evaluate subfoveal choroidal thickness (SCT). Systolic, diastolic, and mean blood pressures (SBP, DBP, and MBP, respectively) were also measured to determine systemic circulatory dynamics at baseline, immediately after immersion (0 min), and 10, 20, and 30 min after immersion.
RESULTS: Immediately after immersion, SBP, DBP, and MBP were significantly declined versus baseline. In contrast, the SCT was significantly increased after warm water immersion. However, all these parameters did not change significantly compared to the baseline within 30 min.
CONCLUSIONS: In the normal eye, parasympathetic nerve activity induced by warming stimuli increases choroidal morphology in response to a decrease in systemic circulatory activity, which normalizes within 30 min. The findings of this study may provide basic data for the prevention and treatment of various choroidal diseases in which sympathetic hyperactivity is involved in the pathogenesis.
摘要：
目的：本研究旨在使用增强深度成像光学相干断层扫描（EDI-OCT）评估足部浸入40°C温水后脉络膜形态的变化过程。
方法：纳入43例健康参与者的43只右眼。使用EDI-OCT确定脉络膜形态的变化以评估中央凹下脉络膜厚度（SCT）。收缩压,舒张压,和平均血压(SBP，DBP,MBP,分别)还进行了测量，以确定基线时的全身循环动力学，浸泡后立即（0分钟），浸泡后10、20和30分钟。
结果：浸泡后立即，SBP,DBP,与基线相比,MBP显著下降.相比之下,温水浸泡后SCT明显增加。然而,所有这些参数在30分钟内与基线相比均无显著变化.
结论：在正常眼中，由温暖刺激引起的副交感神经活动增加脉络膜形态，以响应全身循环活动的减少，在30分钟内正常化。这项研究的结果可能为预防和治疗各种脉络膜疾病提供基础数据，这些疾病的发病机制涉及交感神经功能亢进。
方法：纳入43例健康参与者的43只右眼。使用EDI-OCT确定脉络膜形态的变化以评估中央凹下脉络膜厚度（SCT）。收缩压,舒张压,和平均血压(SBP，DBP,MBP,分别)还进行了测量，以确定基线时的全身循环动力学，浸泡后立即（0分钟），浸泡后10、20和30分钟。
结果：浸泡后立即，SBP,DBP,与基线相比,MBP显著下降.相比之下,温水浸泡后SCT明显增加。然而,所有这些参数在30分钟内与基线相比均无显著变化.
结论：在正常眼中，由温暖刺激引起的副交感神经活动增加脉络膜形态，以响应全身循环活动的减少，在30分钟内正常化。这项研究的结果可能为预防和治疗各种脉络膜疾病提供基础数据，这些疾病的发病机制涉及交感神经功能亢进。
