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Abstract：
Human immunodeficiency virus (HIV) and human T cell leukemia virus (HTLV) have replicative and latent stages of infection. The status of the viruses is dependent on the cells that harbour them and on different events that change the transcriptional and post-transcriptional events. Non-coding (nc)RNAs are key factors in the regulation of retrovirus replication cycles. Notably, micro (mi)RNAs and long non-coding (lnc)RNAs are important regulators that can induce switches between active transcription-replication and latency of retroviruses and have important impacts on their pathogenesis. Here, we review the functions of miRNAs and lncRNAs in the context of HIV and HTLV. We describe how specific miRNAs and lncRNAs are involved in the regulation of the viruses\' transcription, post-transcriptional regulation and latency. We further discuss treatment strategies using ncRNAs for HIV and HTLV long remission, reactivation or possible cure.
摘要：
人类免疫缺陷病毒（HIV）和人类T细胞白血病病毒（HTLV）具有复制和潜伏感染阶段。病毒的状态取决于携带它们的细胞以及改变转录和转录后事件的不同事件。非编码(nc)RNA是调节逆转录病毒复制周期的关键因素。值得注意的是,micro（mi）RNA和长链非编码（lnc）RNA是重要的调节因子，可以诱导逆转录病毒的主动转录复制和潜伏期之间的转换，并对其发病机理具有重要影响。这里,我们回顾了miRNAs和lncRNAs在HIV和HTLV中的功能。我们描述了特定的miRNAs和lncRNAs如何参与病毒转录的调节，转录后调控和潜伏期。我们进一步讨论了使用ncRNAs对HIV和HTLV长期缓解的治疗策略，重新激活或可能的治愈。
