PDF(Pubmed)
Abstract：
Membranous nephropathy has been associated with demyelinating polyneuropathies and antiglomerular membrane disease; however, an association with vasculitic neuropathy has not been described. This case describes a patient with biopsy-proven idiopathic membranous nephropathy and synchronous mononeuritis multiplex secondary to idiopathic small vessel vasculitis, who presented with lower limb microvascular ischaemia, peripheral neuropathy and active urinary sediment. Her extensive non-invasive screening for immunological disease and radiological investigations for occult malignancy were unremarkable. The patient received intravenous methylprednisolone and intravenous rituximab induction therapy resulting in complete remission of both the idiopathic membranous nephropathy and small vessel vasculitis at 7 months post treatment.
摘要：
膜性肾病与脱髓鞘性多发性神经病和抗肾小球膜疾病有关；然而，尚未描述与血管神经病变的关联。该病例描述了一名经活检证实的特发性膜性肾病和特发性小血管血管炎继发的并发多发性单神经炎患者。他患有下肢微血管缺血，周围神经病变和活动性尿沉渣。她对免疫学疾病进行了广泛的非侵入性筛查，对隐匿性恶性肿瘤进行了放射学检查。患者接受静脉注射甲泼尼龙和静脉注射利妥昔单抗诱导治疗，导致特发性膜性肾病和小血管炎在治疗后7个月完全缓解。
