Abstract：
BACKGROUND: Throughout the last decade, a notable increase in HA-filler-related complications have been observed, owing to the increase in demand for filler injections and availability of multiple products.
OBJECTIVE: The aim is to provide practical advice on the best way to prevent and treat HA-filler-related complications.
METHODS: Thirty patients who experienced visible and/or symptomatic complications localized within the facial area were treated according to our algorithm. Patients with inflammatory lesions underwent antibiotic and anti-inflammatory therapy, followed by hyaluronidase injections. Patients with abscesses were treated with antibiotics, incision, and drainage. Each patient completed the dermatology-specific quality of life questionnaire (DLQI) at the first and last examinations.
RESULTS: Among the 29 patients who received antibiotic therapy, 3 healed without further treatment. However, 18 received hyaluronidase injections, 9 underwent incision and drainage, and 5 presented with fistulas and developed retracted scars. Moreover, 80% of the patients were completely healed, 13% significantly improved, and 3% did not show any improvement. The DLQI scores analysis showed a notable impact of patients\' diseases on their quality of life, mainly in the terms of personal relationships and symptoms, with minor impacts on intimate relationships, ability to work, and study. We demonstrated that our algorithm resulted in a significant improvement in the overall quality of life at the last follow-up (p < 0.001).
CONCLUSIONS: The use of filler injections requires caution and specific training because they can lead to serious complications. If these complications are recognized promptly, healing can be optimized. Our treatment algorithm demonstrated high rate of healing and significant improvement in the patients\' quality of life.
OBJECTIVE: The aim is to provide practical advice on the best way to prevent and treat HA-filler-related complications.
METHODS: Thirty patients who experienced visible and/or symptomatic complications localized within the facial area were treated according to our algorithm. Patients with inflammatory lesions underwent antibiotic and anti-inflammatory therapy, followed by hyaluronidase injections. Patients with abscesses were treated with antibiotics, incision, and drainage. Each patient completed the dermatology-specific quality of life questionnaire (DLQI) at the first and last examinations.
RESULTS: Among the 29 patients who received antibiotic therapy, 3 healed without further treatment. However, 18 received hyaluronidase injections, 9 underwent incision and drainage, and 5 presented with fistulas and developed retracted scars. Moreover, 80% of the patients were completely healed, 13% significantly improved, and 3% did not show any improvement. The DLQI scores analysis showed a notable impact of patients\' diseases on their quality of life, mainly in the terms of personal relationships and symptoms, with minor impacts on intimate relationships, ability to work, and study. We demonstrated that our algorithm resulted in a significant improvement in the overall quality of life at the last follow-up (p < 0.001).
CONCLUSIONS: The use of filler injections requires caution and specific training because they can lead to serious complications. If these complications are recognized promptly, healing can be optimized. Our treatment algorithm demonstrated high rate of healing and significant improvement in the patients\' quality of life.
摘要：
背景：在过去的十年中，已观察到HA填充剂相关并发症的显着增加，由于对填充剂注射剂的需求增加和多种产品的可用性。
目的：目的是就预防和治疗HA填充剂相关并发症的最佳方法提供实用建议。
方法：根据我们的算法，对30例面部区域出现可见和/或症状性并发症的患者进行治疗。炎性病变患者接受抗生素和抗炎治疗，然后注射透明质酸酶。脓肿患者接受抗生素治疗，切口,和排水。每位患者在第一次和最后一次检查时都完成了皮肤病学特定的生活质量问卷（DLQI）。
结果：在29名接受抗生素治疗的患者中，3未进一步治疗已痊愈。然而,18人接受透明质酸酶注射，9例行切开引流,5例出现瘘管并形成缩回的疤痕。此外，80%的患者完全痊愈,13%显著提高,3％没有任何改善。DLQI评分分析显示患者疾病对其生活质量有显著影响，主要是在人际关系和症状方面，对亲密关系的影响很小，工作能力,和学习。我们证明了我们的算法在最后一次随访中显著改善了整体生活质量(p<0.001)。
结论：填充剂注射的使用需要谨慎和特定的培训，因为它们会导致严重的并发症。如果这些并发症被及时识别，愈合可以优化。我们的治疗算法证明了高治愈率和患者生活质量的显著改善。
目的：目的是就预防和治疗HA填充剂相关并发症的最佳方法提供实用建议。
方法：根据我们的算法，对30例面部区域出现可见和/或症状性并发症的患者进行治疗。炎性病变患者接受抗生素和抗炎治疗，然后注射透明质酸酶。脓肿患者接受抗生素治疗，切口,和排水。每位患者在第一次和最后一次检查时都完成了皮肤病学特定的生活质量问卷（DLQI）。
结果：在29名接受抗生素治疗的患者中，3未进一步治疗已痊愈。然而,18人接受透明质酸酶注射，9例行切开引流,5例出现瘘管并形成缩回的疤痕。此外，80%的患者完全痊愈,13%显著提高,3％没有任何改善。DLQI评分分析显示患者疾病对其生活质量有显著影响，主要是在人际关系和症状方面，对亲密关系的影响很小，工作能力,和学习。我们证明了我们的算法在最后一次随访中显著改善了整体生活质量(p<0.001)。
结论：填充剂注射的使用需要谨慎和特定的培训，因为它们会导致严重的并发症。如果这些并发症被及时识别，愈合可以优化。我们的治疗算法证明了高治愈率和患者生活质量的显著改善。
