Abstract：
Cats are recognized as significant reservoir hosts for human opisthorchiasis, particularly in areas with a high prevalence of infection. Despite this, the precise role of cats in the transmission of Opisthorchis viverrini between humans and felines remains unclear. This study investigates the association between these two hosts through both spatial and non-spatial analyses in the endemic Thanya sub-district of Thailand. A total of 105 owned cats were randomly sampled from 15 villages within the sub-district for stool examination. A questionnaire was administered to 66 cat owners to explore the human-pet relationship. Household locations were collected using GPS devices. Non-spatial analyses revealed a positive association between the two hosts (P= 0.011; OR 7, 95% CI: 1.6-30.9), highlighting two independent significant risk factors: cat owners consuming raw fish (P = 0.028; OR = 4.52, 95% CI: 1.25-19.45) and feeding cats raw fish (P = 0.011; OR = 16.41, 95% CI: 2.78-317.04) according to multivariate analysis. Spatial analysis provided further support to the non-spatial findings (p = 0.0123; OR = 3.45, 95% CI = 0.88-13.61). Multiple autologistic regression confirmed two significant risk factors: cat owners consuming raw fish (p = 0.054; OR = 3.37, 95% CI: 0.98-11.59) and feeding cats raw fish (p = 0.014; OR = 7.43, 95% CI: 1.49-37.05). Risk mapping identified the western part of the study site as a hotspot for O. viverrini infection. Hyper-endemic focusing revealed a union of human and cat buffers at 0.46 km², with an overlapping area of 0.22 km² (47.83%). This study underscores the impact of owners\' behaviors, specifically consuming and feeding raw fish to cats, on the increased probability of infection in cats. It emphasizes the need for effective opisthorchiasis control through health education targeting cat owners in endemic areas.
摘要：
猫被认为是人类opisthorchiasis的重要宿主，特别是在感染率高的地区。尽管如此,猫在人与猫之间传播Opisthorchisviverrini中的确切作用尚不清楚。本研究通过在泰国特有的Thanya分区进行空间和非空间分析，调查了这两个宿主之间的关联。从该街道的15个村庄中随机抽取了105只拥有的猫进行粪便检查。对66名猫主人进行了问卷调查，以探讨人与宠物的关系。使用GPS设备收集家庭位置。非空间分析显示两个宿主之间呈正相关（P=0.011；OR7，95％CI：1.6-30.9），突出两个独立的显著危险因素:根据多变量分析,猫主人食用生鱼(P=0.028;OR=4.52,95%CI:1.25-19.45)和喂猫生鱼(P=0.011;OR=16.41,95%CI:2.78-317.04)。空间分析为非空间发现提供了进一步的支持（p=0.0123；OR=3.45，95％CI=0.88-13.61）。多重自体回归证实了两个重要的危险因素：猫主人食用生鱼（p=0.054;OR=3.37，95％CI：0.98-11.59）和喂养猫生鱼（p=0.014;OR=7.43，95％CI：1.49-37.05）。风险图谱将研究地点的西部部分确定为O.viverrini感染的热点。超地方性聚焦揭示了人类和猫缓冲区在0.46平方公里的结合，重叠面积0.22平方公里(47.83%)。这项研究强调了业主行为的影响，特别是食用和喂猫生鱼，猫感染的可能性增加。它强调需要通过针对流行地区的猫主人的健康教育来有效控制opisthorchiasis。
