Abstract：
Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Here, the effects and mechanisms of GAA in the treatment of neurological disorders were evaluated and discussed through previous research results. By summarizing previous research results, we found that GAA may play a neuroprotective role through various mechanisms: anti-inflammatory, anti-oxidative stress, anti-apoptosis, protection of nerve cells, and regulation of nerve growth factor. Therefore, GAA is a promising natural neuroprotective agent and this review would contribute to the future development of GAA as a novel clinical candidate drug for treating neurological diseases.
摘要：
灵芝酸A(GAA)是灵芝(GL)中主要的三萜类化合物之一。越来越多的证据表明，GAA显示出多种药理作用，并显示出治疗各种神经系统疾病的潜力。这里,通过以往的研究结果对GAA治疗神经系统疾病的效果和机制进行评价和讨论。通过总结前人的研究成果,我们发现GAA可能通过多种机制发挥神经保护作用：抗炎，抗氧化应激，抗凋亡，保护神经细胞，和神经生长因子的调节。因此,GAA是一种有前途的天然神经保护剂，本综述将有助于GAA作为治疗神经系统疾病的新型临床候选药物的未来发展。
