Abstract：
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective evaluation of the scientific output and status of P2X7R will be instrumental in guiding future research directions. This study aims to present the status and trends of P2X7R research from 2002 to 2023. Publications related to P2X7R were retrieved from the Web of Science Core Collection database. Quantitative analysis and visualization tools were Microsoft Excel, VOSviewer, and CiteSpace software. The analysis content included publication trends, literature co-citation, and keywords. 3282 records were included in total, with the majority of papers published within the last 10 years. Based on literature co-citation and keyword analysis, neuroinflammation, neuropathic pain, gastrointestinal diseases, tumor microenvironment, rheumatoid arthritis, age-related macular degeneration, and P2X7R antagonists were considered to be the hotspots and frontiers of P2X7R research. Researchers will get a more intuitive understanding of the status and trends of P2X7R research from this study.
摘要：
多年来,对P2X7受体（P2X7R）的研究一直在进行。一个全面的,系统，对P2X7R的科学产出和现状进行客观评价将有助于指导未来的研究方向。本研究旨在介绍2002年至2023年P2X7R研究的现状和趋势。从WebofScience核心收藏数据库检索与P2X7R相关的出版物。定量分析和可视化工具是微软Excel，VOSviewer,和CiteSpace软件。分析内容包括出版趋势，文献共引,和关键词。总共包括3282条记录，大多数论文都是在过去的10年中发表的。基于文献共引和关键词分析,神经炎症，神经性疼痛,胃肠道疾病,肿瘤微环境,类风湿性关节炎,年龄相关性黄斑变性,P2X7R拮抗剂被认为是P2X7R研究的热点和前沿。研究人员将从这项研究中更直观地了解P2X7R的研究现状和趋势。
