Abstract：
In light of the important biological activities and widespread applications of organic disulfides, dithiocarbamates, xanthates, thiocarbamates and thiocarbonates, the continual persuit of efficient methods for their synthesis remains crucial. Traditionally, the preparation of such compounds heavily relied on intricate multi-step syntheses and the use of highly prefunctionalized starting materials. Over the past two decades, the direct sulfuration of C-H bonds has evolved into a straightforward, atom- and step-economical method for the preparation of organosulfur compounds. This review aims to provide an up-to-date discussion on direct C-H disulfuration, dithiocarbamation, xanthylation, thiocarbamation and thiocarbonation, with a special focus on describing scopes and mechanistic aspects. Moreover, the synthetic limitations and applications of some of these methodologies, along with the key unsolved challenges to be addressed in the future are also discussed. The majority of examples covered in this review are accomplished via metal-free, photochemical or electrochemical approaches, which are in alignment with the overraching objectives of green and sustainable chemistry. This comprehensive review aims to consolidate recent advancements, providing valuable insights into the dynamic landscape of efficient and sustainable synthetic strategies for these crucial classes of organosulfur compounds.
摘要：
鉴于有机二硫化物的重要生物活性和广泛应用,二硫代氨基甲酸酯，黄药,硫代氨基甲酸酯和硫代碳酸盐，持续有效的合成方法仍然至关重要。传统上,这些化合物的制备严重依赖于复杂的多步合成和使用高度预官能化的起始材料。在过去的二十年里，C-H键的直接硫化已经演变成一种简单的，制备有机硫化合物的原子和分步经济方法。这篇综述旨在提供关于直接C-H二硫化的最新讨论，二硫代氨基甲酸盐，黄原化,硫代氨基甲酸和硫代碳酸化，特别侧重于描述范围和机械方面。此外，其中一些方法的合成限制和应用，还讨论了未来有待解决的关键挑战。本综述涵盖的大多数示例都是通过无金属，光化学或电化学方法，这符合绿色和可持续化学的总体目标。这项全面审查旨在巩固最近的进展，为这些关键类别的有机硫化合物提供有效和可持续合成策略的动态景观的宝贵见解。
