Mesh : Humans Sex Cord-Gonadal Stromal Tumors / pathology Female Ovarian Neoplasms / pathology Biomarkers, Tumor / analysis genetics

来  源:   DOI:10.1097/PAP.0000000000000436

Abstract:
We review the time honored but still frequently challenging features of ovarian sex cord-stromal tumors and also emphasize new developments, including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part to the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr. Robert E. Scully. In part I, we reviewed the pure ovarian stromal tumors. Now, in part II, we present the major clinical, pathologic, and genomic features of pure sex cord and sex cord-stromal tumors.
摘要:
我们回顾了历史悠久但仍然经常具有挑战性的卵巢性索间质肿瘤的特征,并强调了新的发展。包括不寻常的形态表现,尽管许多肿瘤相对罕见,导致不成比例的鉴别诊断问题,变异的免疫组织化学谱,以及特定的分子和综合征关联。这些肿瘤也具有历史意义,因为目前的知识仍然很大程度上取决于两个妇科病理学巨人的贡献,罗伯特·迈耶博士和罗伯特·E·史卡利博士。在第一部分,我们回顾了单纯的卵巢间质瘤。现在,在第二部分,我们提出了主要的临床,病理性,纯性索和性索间质肿瘤的基因组特征。
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