PDF(Pubmed)
Abstract：
BACKGROUND: The toxic effects of heavy metals on biological systems are being investigated with increasing interest day by day. Our purpose was to investigate heavy metals such as aluminum (Al), cadmium (Cd), arsenic (As), lead (Pb), and nickel (Ni) in males with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether there is a relationship between heavy metals and testosterone levels.
METHODS: Twenty-six male patients with IHH aged 18-50 and 22 healthy males aged 21-50 admitted to the Outpatient Department of Endocrinology for follow-up were enrolled. BMIs were calculated by measuring the height and weight of all participants. Al, Cd, As, Pb, and Ni levels were measured and compared between groups. Testosterone levels were measured to investigate whether there was a correlation with heavy metal levels.
RESULTS: Al, Cd, As, Pb, and Ni levels were statistically higher in the patient group compared to the control group (p<0.001). A moderately strong significant negative correlation was detected between the patients\' testosterone and As levels (p=0.001, r=-0.609, R2=0.371). Decreased As and Cd levels were observed as the patients\' ages increased (p=0.013, r=-0.471).
CONCLUSIONS: Heavy metals might play potential roles in IHH. We hope that investigating heavy metal levels in IHH and adding toxicity-preventive treatments to hormonal therapies will be beneficial in the multifaceted management of the disease in clinical practice.
METHODS: Twenty-six male patients with IHH aged 18-50 and 22 healthy males aged 21-50 admitted to the Outpatient Department of Endocrinology for follow-up were enrolled. BMIs were calculated by measuring the height and weight of all participants. Al, Cd, As, Pb, and Ni levels were measured and compared between groups. Testosterone levels were measured to investigate whether there was a correlation with heavy metal levels.
RESULTS: Al, Cd, As, Pb, and Ni levels were statistically higher in the patient group compared to the control group (p<0.001). A moderately strong significant negative correlation was detected between the patients\' testosterone and As levels (p=0.001, r=-0.609, R2=0.371). Decreased As and Cd levels were observed as the patients\' ages increased (p=0.013, r=-0.471).
CONCLUSIONS: Heavy metals might play potential roles in IHH. We hope that investigating heavy metal levels in IHH and adding toxicity-preventive treatments to hormonal therapies will be beneficial in the multifaceted management of the disease in clinical practice.
摘要：
背景：重金属对生物系统的毒性作用日益受到人们的关注。我们的目的是研究重金属，如铝(Al)，镉(Cd),砷（As），铅(Pb),和镍（Ni）在特发性低促性腺激素性性腺功能减退（IHH）的男性中，并确定重金属与睾丸激素水平之间是否存在关系。
方法：纳入内分泌科门诊随访的26例18-50岁男性IHH患者和22例21-50岁健康男性患者。通过测量所有参与者的身高和体重来计算BMI。Al,Cd,As,Pb,测量并比较各组之间的Ni水平。测量睾酮水平以调查是否与重金属水平相关。
结果：Al，Cd,As,Pb,与对照组相比，患者组的Ni水平在统计学上较高（p<0.001）。在患者睾酮和As水平之间检测到中等强度的显著负相关(p=0.001,r=-0.609,R2=0.371)。随着患者年龄的增加，As和Cd水平降低（p=0.013，r=-0.471）。
结论：重金属可能在IHH中起潜在作用。我们希望研究IHH中的重金属水平并在激素疗法中增加毒性预防性治疗将有益于临床实践中对该疾病的多方面管理。
方法：纳入内分泌科门诊随访的26例18-50岁男性IHH患者和22例21-50岁健康男性患者。通过测量所有参与者的身高和体重来计算BMI。Al,Cd,As,Pb,测量并比较各组之间的Ni水平。测量睾酮水平以调查是否与重金属水平相关。
结果：Al，Cd,As,Pb,与对照组相比，患者组的Ni水平在统计学上较高（p<0.001）。在患者睾酮和As水平之间检测到中等强度的显著负相关(p=0.001,r=-0.609,R2=0.371)。随着患者年龄的增加，As和Cd水平降低（p=0.013，r=-0.471）。
结论：重金属可能在IHH中起潜在作用。我们希望研究IHH中的重金属水平并在激素疗法中增加毒性预防性治疗将有益于临床实践中对该疾病的多方面管理。
