PDF(Pubmed)
Abstract：
UNASSIGNED: During aging, cerebral structures undergo changes due to oxidative stress. The consumption of some plants seems to improve neurological health. For example, rosemary extract (RE) which is widely used as a flavoring food has anti-inflammatory and anti-oxidant activities. Therefore, we aimed to study the effect of RE on the changes related to the aging process in the prefrontal cortex (PFC).
UNASSIGNED: Twenty-four male Wistar rats including young and old were purchased. Each group was divided into two subgroups: vehicle and rosemary (old vehicle (OV), old rosemary (OR), young vehicle (YV), and young rosemary (YR) groups). Then, we examined the number of intact neurons, myelin base protein (MBP), white matter (WM), levels of malondialdehyde (MDA), and glutathione peroxidase (GPx) in the PFC.
UNASSIGNED: The results showed that in the old vehicle rats compared to the young group without treatment, except for the MDA level (which increased), other variables significantly decreased (P≤0.05). Additionally, RE consumption demonstrated a significant elevation of WMA, MBP intensity, number of intact neurons, and GPx activity level, while MDA levels significantly reduced in the treated old rats compared to the old vehicle group (P≤0.05). However, there was no significant difference between the OR and YV groups (P≥0.05).
UNASSIGNED: Overall, it seems that RE can protect and improve aging damages in the PFC due to its anti-oxidant properties. So, the use of RE can be a suitable strategy to prevent aging complications in the brain.
UNASSIGNED: Twenty-four male Wistar rats including young and old were purchased. Each group was divided into two subgroups: vehicle and rosemary (old vehicle (OV), old rosemary (OR), young vehicle (YV), and young rosemary (YR) groups). Then, we examined the number of intact neurons, myelin base protein (MBP), white matter (WM), levels of malondialdehyde (MDA), and glutathione peroxidase (GPx) in the PFC.
UNASSIGNED: The results showed that in the old vehicle rats compared to the young group without treatment, except for the MDA level (which increased), other variables significantly decreased (P≤0.05). Additionally, RE consumption demonstrated a significant elevation of WMA, MBP intensity, number of intact neurons, and GPx activity level, while MDA levels significantly reduced in the treated old rats compared to the old vehicle group (P≤0.05). However, there was no significant difference between the OR and YV groups (P≥0.05).
UNASSIGNED: Overall, it seems that RE can protect and improve aging damages in the PFC due to its anti-oxidant properties. So, the use of RE can be a suitable strategy to prevent aging complications in the brain.
摘要：
■在老化过程中，由于氧化应激，大脑结构会发生变化。食用一些植物似乎可以改善神经系统健康。例如,迷迭香提取物(RE)具有抗炎和抗氧化活性,被广泛用作调味食品。因此,我们旨在研究RE对前额叶皮层（PFC）衰老过程相关变化的影响。
■购买了24只雄性Wistar大鼠,包括幼年和老年。每组分为两个子组：车辆和迷迭香（旧车辆（OV），老迷迭香（或），年轻车辆（YV），和年轻迷迭香（YR）组）。然后，我们检查了完整神经元的数量，髓鞘碱性蛋白（MBP），白质（WM），丙二醛（MDA）的水平，和PFC中的谷胱甘肽过氧化物酶(GPx)。
■结果显示，在老年媒介物大鼠中，与未治疗的青年组相比，除了MDA水平（增加），其他变量显著降低(P≤0.05)。此外,稀土消耗量显着提高了WMA，MBP强度,完整神经元的数量，和GPx活动水平，而MDA水平在治疗的老年大鼠中显著降低,与老年载体组相比(P≤0.05)。然而,OR组和YV组之间差异无统计学意义(P≥0.05)。
■总的来说，由于其抗氧化性能，RE似乎可以保护和改善PFC中的老化损伤。所以,使用RE可以是预防大脑老化并发症的合适策略。
■购买了24只雄性Wistar大鼠,包括幼年和老年。每组分为两个子组：车辆和迷迭香（旧车辆（OV），老迷迭香（或），年轻车辆（YV），和年轻迷迭香（YR）组）。然后，我们检查了完整神经元的数量，髓鞘碱性蛋白（MBP），白质（WM），丙二醛（MDA）的水平，和PFC中的谷胱甘肽过氧化物酶(GPx)。
■结果显示，在老年媒介物大鼠中，与未治疗的青年组相比，除了MDA水平（增加），其他变量显著降低(P≤0.05)。此外,稀土消耗量显着提高了WMA，MBP强度,完整神经元的数量，和GPx活动水平，而MDA水平在治疗的老年大鼠中显著降低,与老年载体组相比(P≤0.05)。然而,OR组和YV组之间差异无统计学意义(P≥0.05)。
■总的来说，由于其抗氧化性能，RE似乎可以保护和改善PFC中的老化损伤。所以,使用RE可以是预防大脑老化并发症的合适策略。
