PDF(Pubmed)
Abstract：
Generalized pustular psoriasis is defined as a primary, sterile, macroscopically visible pustular eruption on non-acral skin, which can occur with or without systemic inflammation and/or psoriasis vulgaris, and can either be relapsing or be persistent, according to the European Rare and Severe Psoriasis Expert Network. The treatment of generalized pustular psoriasis may be challenging. We describe a 48-year-old woman with a 15-year history of severe generalized pustular psoriasis and plaque psoriasis resistant to multiple courses of treatments with conventional and biological agents who had a rapid, complete and durable (up to 12 months) clinical remission with spesolimab, an anti-interleukin-36 receptor antagonist monoclonal antibody recently approved for the treatment of generalized pustular psoriasis flares.
摘要：
广义脓疱型银屑病被定义为原发性，无菌,在非肢端皮肤上宏观可见脓疱，可以在有或没有全身性炎症和/或寻常型牛皮癣的情况下发生，既可以复发，也可以持续，根据欧洲罕见和严重银屑病专家网络。全身性脓疱型银屑病的治疗可能具有挑战性。我们描述了一名48岁的女性，有15年的严重的全身性脓疱型银屑病和斑块型银屑病病史，对常规和生物制剂的多个疗程具有抗性，使用spesolimab的完全和持久（长达12个月）临床缓解，抗白细胞介素-36受体拮抗剂单克隆抗体最近被批准用于治疗全身性脓疱型银屑病。
