Abstract：
Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one of the major pathophysiological mechanisms responsible for the progression of diabetes complications such as non-alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly to the toxic effects of diabetes on periodontitis. Therefore, we reviewed the current in vivo, in vitro, and clinical evidence of the detrimental effects of lipotoxicity on periodontitis, focusing on its molecular mechanisms, especially oxidative and endoplasmic reticulum stress, inflammation, ceramides, adipokines, and programmed cell death pathways. By elucidating potential therapeutic strategies targeting lipotoxicity and describing their associated mechanisms and clinical outcomes, including metformin, statins, liraglutide, adiponectin, and omega-3 PUFA, this review seeks to provide a more comprehensive and effective treatment framework against diabetes-associated periodontitis. Furthermore, the challenges and future research directions are proposed, aiming to contribute to a more profound understanding of the impact of lipotoxicity on periodontitis.
摘要：
脂毒性是指脂质在除脂肪组织(体脂肪)以外的组织中的积累。它是导致糖尿病并发症如非酒精性脂肪性肝病和糖尿病肾病进展的主要病理生理机制之一。越来越多的证据表明，脂毒性也显着导致糖尿病对牙周炎的毒性作用。因此,我们回顾了目前的体内情况，在体外，以及脂毒性对牙周炎有害影响的临床证据，专注于其分子机制，尤其是氧化和内质网应激，炎症,神经酰胺,脂肪因子,和程序性细胞死亡途径。通过阐明针对脂毒性的潜在治疗策略并描述其相关机制和临床结果，包括二甲双胍,他汀类药物，利拉鲁肽,脂联素,和omega-3PUFA，本综述旨在为糖尿病相关牙周炎提供更全面有效的治疗框架.此外，提出了挑战和未来的研究方向，旨在有助于更深刻地了解脂毒性对牙周炎的影响。
