Abstract：
A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD.
摘要：
尽管用兰索拉唑和vonoprazan治疗，但一名30岁的特发性消化性溃疡（IPUD）患者的溃疡性出血反复复发。进一步的评估表明，溃疡的原因是胃窦的强烈收缩运动。这促使马来酸曲美布汀（TM）和vonoprazan的共同给药以缓解胃收缩。TM可有效预防溃疡性出血的复发，患者已经缓解了4年。该病例强调了TM在治疗IPUD中的潜在功效以及在IPUD病例中将收缩性过度视为根本原因的重要性。
