Abstract：
Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without appropriate treatment. Although viral infection is the most common trigger of hemophagocytic lymphohistiocytosis, cases of herpes simplex virus type 1-induced hemophagocytic lymphohistiocytosis are rare in adults. This study aims to provide a comprehensive overview of the clinical characteristics and treatment outcomes associated with HSV-1-induced HLH. We herein report an adult case of hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1, diagnosed on the basis of peripheral blood metagenomic next-generation sequencing results. The patient exhibited a favorable response to treatment, involving dexamethasone, intravenous immunoglobulin, and acyclovir. Notably, etoposide administration was deemed unnecessary, and there has been no recurrence of the disease within the year following treatment. Early and sensitive recognition, rapid and precise diagnosis, and timely and appropriate treatment facilitated the successful treatment of this case.
摘要：
噬血细胞淋巴组织细胞增生症是一种严重的高炎症综合征，如果没有适当的治疗，可能会危及生命。尽管病毒感染是噬血细胞淋巴组织细胞增生症最常见的触发因素，单纯疱疹病毒1型诱导的噬血细胞性淋巴组织细胞增生症在成人中很少见。本研究旨在提供与HSV-1诱导的HLH相关的临床特征和治疗结果的全面概述。我们在此报告了1例由单纯疱疹病毒1型引起的噬血细胞淋巴组织细胞增多症的成人病例，该病例是根据外周血宏基因组下一代测序结果诊断的。患者对治疗表现出良好的反应，涉及地塞米松，静脉注射免疫球蛋白，和阿昔洛韦.值得注意的是,依托泊苷给药被认为是不必要的，治疗后一年内没有复发。早期和敏感的识别，快速准确的诊断，及时和适当的治疗促进了该病例的成功治疗。
