Abstract：
OBJECTIVE: Tori and exostoses are considered risk factors for the development of medication-related osteonecrosis of the jaw (MRONJ). The aims of this study were to present the prevalence of MRONJ located at tori in the Copenhagen ONJ Cohort, evaluate the surgical treatment of MRONJ located at tori and explore trauma to tori as an additional risk factor in patients on antiresorptive medication.
METHODS: Data from a consecutive series of 506 patients with MRONJ (Copenhagen ONJ Cohort) were reviewed for the presence of tori and MRONJ located at tori. Demographic and medical data were analyzed, and healing outcomes and pain after the prophylactic removal of tori, surgical treatment of MRONJ located at tori, and conservative treatment of MRONJ located at tori were evaluated and compared using Fisher\'s exact test.
RESULTS: MRONJ located at tori was frequent and could be identified in 53% of the patients with tori, which accounts for a prevalence of 5.1% in the entire cohort. Of the 28 surgically treated patients, 27 (96.4%) healed uneventfully with no exposed bone after their first or second revision surgery. Fourteen (41.2%) patients with tori underwent therapeutic removal, eight (23.5%) underwent prophylactic removal, and six (17.6%) underwent both therapeutic and prophylactic removals. Two (33.3%) of the six conservatively treated patients healed spontaneously. Both treatment types resulted in a significant decrease in pain.
CONCLUSIONS: Prophylactic and therapeutic surgical removal of tori are reliable treatments and should be considered if a patient\'s general health allows surgery.
BACKGROUND: The study was approved by the Regional Scientific Ethical Committee (H-6-2013-010) on November 20, 2013, and was retrospectively registered.
METHODS: Data from a consecutive series of 506 patients with MRONJ (Copenhagen ONJ Cohort) were reviewed for the presence of tori and MRONJ located at tori. Demographic and medical data were analyzed, and healing outcomes and pain after the prophylactic removal of tori, surgical treatment of MRONJ located at tori, and conservative treatment of MRONJ located at tori were evaluated and compared using Fisher\'s exact test.
RESULTS: MRONJ located at tori was frequent and could be identified in 53% of the patients with tori, which accounts for a prevalence of 5.1% in the entire cohort. Of the 28 surgically treated patients, 27 (96.4%) healed uneventfully with no exposed bone after their first or second revision surgery. Fourteen (41.2%) patients with tori underwent therapeutic removal, eight (23.5%) underwent prophylactic removal, and six (17.6%) underwent both therapeutic and prophylactic removals. Two (33.3%) of the six conservatively treated patients healed spontaneously. Both treatment types resulted in a significant decrease in pain.
CONCLUSIONS: Prophylactic and therapeutic surgical removal of tori are reliable treatments and should be considered if a patient\'s general health allows surgery.
BACKGROUND: The study was approved by the Regional Scientific Ethical Committee (H-6-2013-010) on November 20, 2013, and was retrospectively registered.
摘要：
目的：托里和外生骨被认为是药物相关性颌骨坏死（MRONJ）发展的危险因素。这项研究的目的是介绍位于哥本哈根ONJ队列托里的MRONJ的患病率，评估位于托里的MRONJ的手术治疗，并探讨托里创伤作为抗再吸收药物患者的另一个危险因素。
方法：回顾了连续506例MRONJ患者（哥本哈根ONJ队列）的数据，以了解是否存在Tori和位于Tori的MRONJ。人口统计学和医学数据进行了分析，预防性切除托里后的愈合结果和疼痛，位于托里的MRONJ的手术治疗，使用Fisher精确检验对位于托里的MRONJ的保守治疗进行评估和比较。
结果：位于托里的MRONJ很常见，并且可以在53％的托里患者中发现，在整个队列中占5.1%的患病率。在28名经手术治疗的患者中，27（96.4％）在第一次或第二次翻修手术后愈合顺利，没有裸露的骨头。14名(41.2%)托里患者接受了治疗性切除，8人(23.5%)接受了预防性切除，6人(17.6%)接受了治疗性和预防性切除。六名保守治疗的患者中有两名（33.3％）自发愈合。两种治疗类型均导致疼痛显著减轻。
结论：预防性和治疗性手术切除托里是可靠的治疗方法，如果患者的一般健康状况允许手术，应考虑。
背景：该研究于2013年11月20日获得区域科学伦理委员会（H-6-2013-010）的批准，并进行了回顾性注册。
方法：回顾了连续506例MRONJ患者（哥本哈根ONJ队列）的数据，以了解是否存在Tori和位于Tori的MRONJ。人口统计学和医学数据进行了分析，预防性切除托里后的愈合结果和疼痛，位于托里的MRONJ的手术治疗，使用Fisher精确检验对位于托里的MRONJ的保守治疗进行评估和比较。
结果：位于托里的MRONJ很常见，并且可以在53％的托里患者中发现，在整个队列中占5.1%的患病率。在28名经手术治疗的患者中，27（96.4％）在第一次或第二次翻修手术后愈合顺利，没有裸露的骨头。14名(41.2%)托里患者接受了治疗性切除，8人(23.5%)接受了预防性切除，6人(17.6%)接受了治疗性和预防性切除。六名保守治疗的患者中有两名（33.3％）自发愈合。两种治疗类型均导致疼痛显著减轻。
结论：预防性和治疗性手术切除托里是可靠的治疗方法，如果患者的一般健康状况允许手术，应考虑。
背景：该研究于2013年11月20日获得区域科学伦理委员会（H-6-2013-010）的批准，并进行了回顾性注册。
