关键词: Cellular immunity Cáncer gástrico Eventos tromboembólicos Gastric cancer Inmunidad celular PDL-1 Thromboembolic events

Mesh : Female Humans Male Middle Aged B7-H1 Antigen Incidence Retrospective Studies Stomach Neoplasms / immunology Venous Thrombosis / etiology epidemiology

来  源:   DOI:10.1016/j.medcli.2024.01.003

Abstract:
Gastric cancer is one of the cancers most associated with thromboembolic phenomena. The objective of this article is to study if there is a correlation between thromboembolic phenomena in gastric cancer and tumor expression of PDL-1.
To this end, the association between thromboembolic events and PDL-1 expression was retrospectively studied in a sample of 46 patients from our hospital.
The results obtained revealed a statistically significant difference between the percentage of thromboembolic events between positive and negative PDL-1 with an increase in the latter with a P value of 0.034.
In conclusion, the expression of PDL-1, and with it, of an inhibitory factor of the cellular immune response, correlates with a decrease in thromboembolic events in patients with gastric cancer, which could indicate the crucial role of the immune response in which thromboembolic events occur.
摘要:
背景:胃癌是与血栓栓塞现象最相关的癌症之一。本文的目的是研究胃癌血栓栓塞现象与PDL-1的肿瘤表达之间是否存在相关性。
方法:为此,我们在我院46例患者的样本中回顾性研究了血栓栓塞事件与PDL-1表达之间的相关性.
结果:获得的结果表明,PDL-1阳性和阴性之间的血栓栓塞事件百分比之间存在统计学上的显着差异,后者的P值为0.034。
结论:结论:PDL-1的表达,细胞免疫反应的抑制因子,与胃癌患者血栓栓塞事件的减少相关,这可能表明发生血栓栓塞事件的免疫反应的关键作用。
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