PDF(Pubmed)
Abstract：
BACKGROUND: Prematurity is an urgent public health problem worldwide. Recent studies associate maternal hypovitaminosis D during pregnancy with an increased risk of prematurity. However, the evidence on this association remains inconclusive, and there is lack of consensus in the literature. The exact mechanism by which low vitamin D levels may increase the risk of preterm birth is not yet fully understood. Nevertheless, it is known that vitamin D may play a role in maintaining a healthy pregnancy by regulating inflammation and immunomodulation by acting on the maternal and fetal immune systems. Inflammation and immune dysregulation are both associated with preterm birth, and low vitamin D levels may exacerbate these processes. The results of this review may have important implications for clinical practice and public health policy, particularly regarding vitamin D supplementation during pregnancy.
METHODS: A systematic review of the literature will be conducted. The search will be performed in electronic databases: CINAHL; MEDLINE; Cochrane Central Register of Controlled Trials; Cochrane Library; Academic Search Complete; Information Science and Technology Abstracts; MedicLatina; SCOPUS; PubMed; and Google Scholar, with the chronological range of January 2018 to November 2022. The search strategy will include the following Medical Subject Headings or similar terms: \'Vitamin D\'; \'25-hydroxyvitamin D\'; \'Hypovitaminosis D\'; \'Pregnancy\'; \'Pregnant women\'; \'Expectant mother\'; \'Prematurity\'; \'Premature birth\'; \'Premature delivery\'; \'Preterm birth\'; and \'Preterm labour\'. This review will include quantitative primary studies, both experimental (clinical trials) and observational (cohort, cross-sectional, and case-control). The quality of each selected study and the results obtained will be assessed by two reviewers separately, using the Cochrane risk of bias tool for evaluating randomised clinical trials or the Newcastle Ottawa Scale for non-randomised studies, following the respective checklist. In case of disagreement, a third reviewer will be consulted.
BACKGROUND: This study does not involve human subjects and therefore does not require ethics approval. The results will be disseminated through publication in a peer-reviewed scientific journal and through conference presentations. All changes made to the protocol will be registered in PROSPERO, with information on the nature and justification for the changes made.
UNASSIGNED: CRD42022303901.
METHODS: A systematic review of the literature will be conducted. The search will be performed in electronic databases: CINAHL; MEDLINE; Cochrane Central Register of Controlled Trials; Cochrane Library; Academic Search Complete; Information Science and Technology Abstracts; MedicLatina; SCOPUS; PubMed; and Google Scholar, with the chronological range of January 2018 to November 2022. The search strategy will include the following Medical Subject Headings or similar terms: \'Vitamin D\'; \'25-hydroxyvitamin D\'; \'Hypovitaminosis D\'; \'Pregnancy\'; \'Pregnant women\'; \'Expectant mother\'; \'Prematurity\'; \'Premature birth\'; \'Premature delivery\'; \'Preterm birth\'; and \'Preterm labour\'. This review will include quantitative primary studies, both experimental (clinical trials) and observational (cohort, cross-sectional, and case-control). The quality of each selected study and the results obtained will be assessed by two reviewers separately, using the Cochrane risk of bias tool for evaluating randomised clinical trials or the Newcastle Ottawa Scale for non-randomised studies, following the respective checklist. In case of disagreement, a third reviewer will be consulted.
BACKGROUND: This study does not involve human subjects and therefore does not require ethics approval. The results will be disseminated through publication in a peer-reviewed scientific journal and through conference presentations. All changes made to the protocol will be registered in PROSPERO, with information on the nature and justification for the changes made.
UNASSIGNED: CRD42022303901.
摘要：
背景：早产是全球范围内紧迫的公共卫生问题。最近的研究将妊娠期母体维生素D缺乏症与早产风险增加联系起来。然而,关于这个协会的证据仍然没有定论，文献中缺乏共识。低维生素D水平可能增加早产风险的确切机制尚未完全了解。然而，众所周知，维生素D可能通过作用于母体和胎儿的免疫系统来调节炎症和免疫调节，从而在维持健康妊娠中发挥作用。炎症和免疫失调都与早产有关，低维生素D水平可能会加剧这些过程。本综述的结果可能对临床实践和公共卫生政策具有重要意义。特别是在怀孕期间补充维生素D。
方法：将对文献进行系统回顾。搜索将在电子数据库中进行：CINAHL；MEDLINE；Cochrane中央对照试验注册；Cochrane图书馆；学术搜索完成；信息科学和技术文摘；MedicLatina；SCOPUS；PubMed；和GoogleScholar，时间顺序为2018年1月至2022年11月。搜索策略将包括以下医学主题词：\'维生素D\';\'25-羟基维生素D\';\'维生素D缺乏症\';\'怀孕\';\'孕妇\';\'准妈妈\';\'早产\';\'早产\';\'早产\';\'早产\';这篇综述将包括定量的初步研究，实验(临床试验)和观察(队列，横截面,和病例控制)。每个选定研究的质量和获得的结果将分别由两名评审员评估，使用Cochrane偏倚风险工具评估随机临床试验或纽卡斯尔渥太华量表进行非随机研究，按照各自的检查表。如果有分歧,将咨询第三位审稿人。
背景：这项研究不涉及人类受试者，因此不需要伦理学批准。结果将通过在同行评审的科学期刊上发表和通过会议介绍来传播。对协议所做的所有更改都将在PROSPERO中注册，提供有关更改的性质和理由的信息。
■CRD42022303901。
方法：将对文献进行系统回顾。搜索将在电子数据库中进行：CINAHL；MEDLINE；Cochrane中央对照试验注册；Cochrane图书馆；学术搜索完成；信息科学和技术文摘；MedicLatina；SCOPUS；PubMed；和GoogleScholar，时间顺序为2018年1月至2022年11月。搜索策略将包括以下医学主题词：\'维生素D\';\'25-羟基维生素D\';\'维生素D缺乏症\';\'怀孕\';\'孕妇\';\'准妈妈\';\'早产\';\'早产\';\'早产\';\'早产\';这篇综述将包括定量的初步研究，实验(临床试验)和观察(队列，横截面,和病例控制)。每个选定研究的质量和获得的结果将分别由两名评审员评估，使用Cochrane偏倚风险工具评估随机临床试验或纽卡斯尔渥太华量表进行非随机研究，按照各自的检查表。如果有分歧,将咨询第三位审稿人。
背景：这项研究不涉及人类受试者，因此不需要伦理学批准。结果将通过在同行评审的科学期刊上发表和通过会议介绍来传播。对协议所做的所有更改都将在PROSPERO中注册，提供有关更改的性质和理由的信息。
■CRD42022303901。
