Abstract：
Drug-eluting contact lenses (DECLs) incorporated with poly(lactic-co-glycolic acid) (PLGA) and various model drugs (ketotifen fumarate, bimatoprost and latanoprost) were fabricated using nanoelectrospray (nES) approach. The resulting DECLs demonstrated outstanding optical transmittance within the optical zone, indicating that the employed coating procedure did not compromise visual acuity under the prescribed spraying parameters. In vitro drug release assessments of the model drugs (ketotifen fumarate (KF), bimatoprost (BIM), and latanoprost (LN)) revealed a strong correlation between the model drug\'s hydrophobicity and the duration of drug release. Changing the drug loading of the more hydrophilic model drugs, BIM and KF, showed no impact on the drug release kinetics of DECLs loaded with BIM and KF. However, for the hydrophobic model drug, LN, the highest LN loading led to the most extended drug release. The conventional steam sterilisation method was found to damage the PLGA coating on the DECLs fabricated by nES. An alternative sterilisation strategy, such as radiation sterilisation may need to be investigated in the future study to minimise potential harm to the coating.
摘要：
药物洗脱隐形眼镜（DECL）与聚（乳酸-乙醇酸共聚物）（PLGA）和各种模型药物（富马酸酮替芬，比马前列素和拉坦前列素）是使用纳米电喷雾（nES）方法制造的。所得的DECLs在光学区内表现出出色的光学透射率，表明在规定的喷涂参数下，采用的涂层程序不会损害视力。模型药物（富马酸酮替芬（KF），比马前列素(BIM),和拉坦前列素（LN））揭示了模型药物的疏水性与药物释放持续时间之间的强相关性。改变更亲水的模型药物的载药量，BIM和KF,显示对负载有BIM和KF的DECL的药物释放动力学没有影响。然而,对于疏水模型药物，LN,最高的LN负载导致最延长的药物释放。发现常规蒸汽灭菌方法会损坏nES制造的DECL上的PLGA涂层。另一种绝育策略，例如辐射消毒可能需要在未来的研究中进行研究，以尽量减少对涂层的潜在伤害。
