Abstract：
Air pollution is an environmental stimulus that may predispose pregnant women to preterm rapture of membrane (PROM). However, the relationship of maternal exposure to air pollutants and PROM is still unclear. To investigate the relationship between the long-term and short-term maternal exposure to air pollution and PROM. We searched all studies published in PubMed, Embase and Web of Science up to February 2024. The studies provided quantitative effect estimates with 95% confidence intervals, for the impact of short-term (<30 days) or long-term (≥30 days) maternal exposure to air pollutants on PROM, preterm PROM (PPROM) or term PROM (TPROM). The odds ratio (OR), risk ratio (RR), or hazard ratio (HR), with 95% confidence intervals was extracted, and RR or HR were deemed as OR because of the low prevalence of PROM. Fixed- or random-effects meta-analyses performed. In total, 17 relevant studies were included. Maternal exposure to PM2.5 in the second trimester increases the risk of PROM (pooled OR = 1.15, 95%CI: 1.05-1.26). Maternal exposure to PM10, NO2, NO, CO and SO2 during pregnancy and short-term maternal exposure to PM2.5, NO2, SO2 and O3 also associate with PROM occurrence. The results of the study show that both long-term maternal exposure in the second or third trimester and short-term maternal exposure to ambient air pollution can increase the risk of PROM.
摘要：
空气污染是一种环境刺激，可能使孕妇容易早产膜破裂（PROM）。然而,母体暴露于空气污染物与胎膜早破的关系尚不清楚.探讨孕妇长期和短期空气污染暴露与胎膜早破的关系。我们搜索了发表在PubMed上的所有研究，Embase和WebofScience至2024年2月。这些研究提供了95%置信区间的定量效应估计，对于短期（<30天）或长期（≥30天）母体暴露于空气污染物对胎膜早破的影响，早产PROM（PPROM）或学期PROM（TPROM）。赔率比(OR)，风险比(RR)，或危险比(HR)，提取95%的置信区间，RR或HR被认为是OR，因为PROM的患病率较低。进行固定或随机效应荟萃分析。总的来说,共纳入17项相关研究。孕妇在妊娠中期暴露于PM2.5会增加PROM的风险（合并OR=1.15，95CI：1.05-1.26）。母体暴露于PM10，NO2，NO，妊娠期间的CO和SO2以及母亲短期暴露于PM2.5，NO2，SO2和O3也与PROM的发生有关。研究结果表明，孕妇在第二或第三三个月的长期暴露和孕妇在环境空气污染中的短期暴露都会增加胎膜早破的风险。
