Abstract：
Adaptive drug release can combat coagulation and inflammation activation at the blood-material interface with minimized side effects. For that purpose, poly(styrene-alt-maleic-anhydride) copolymers were conjugated to heparin via coagulation-responsive linker peptides and shown to tightly adsorb onto poly(ethersulfone) (PES)-surfaces from aqueous solutions as monolayers. Coagulation-responsive release of unfractionated as well as low molecular weight heparins from the respective coatings was demonstrated to be functionally beneficial in human plasma and whole blood incubation with faster release kinetics resulting in stronger anticoagulant effects. Coated poly(ethersulfone)/poly(vinylpyrrolidone) (PES/PVP) flat membranes proved the technology to offer an easy, effective and robust anticoagulant interfacial functionalization of hemodialysis membranes. In perspective, the modularity of the adaptive release system will be used for inhibiting multiple activation processes.
摘要：
适应性药物释放可以对抗血液-材料界面处的凝血和炎症活化,具有最小化的副作用。为此,聚（苯乙烯-alt-马来酸酐）共聚物通过凝血响应接头肽与肝素缀合，并显示出从水溶液中以单层形式紧密吸附到聚（醚砜）（PES）表面上。未分级的以及低分子量肝素从各自的涂层中的凝血响应释放被证明在人血浆和全血孵育中具有功能上的益处,具有更快的释放动力学,导致更强的抗凝血作用。涂层聚(醚砜)/聚(乙烯基吡咯烷酮)(PES/PVP)平膜证明了该技术提供一种简单的,血液透析膜的有效和强大的抗凝血界面功能化。在透视中,自适应释放系统的模块化将用于抑制多个激活过程。
