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Abstract：
OBJECTIVE: Tortuosity of the internal carotid artery (ICA) is associated with intracranial aneurysms (IAs). The siphon is the most curved segment of the ICA, but its morphology has controversial effects on IAs. This study aimed to explore the morphometric features of the siphon and the potential hemodynamic mechanisms that may affect C7 aneurysm formation.
METHODS: In this study 32 patients with C7 aneurysms diagnosed at Xiangya Hospital between 2019 and 2021 and 32 control subjects were enrolled after propensity score matching. Computed tomography angiography (CTA) images were acquired to measure morphologic features, and then, by combining clinical data, simplified carotid siphon models were constructed, and computational fluid dynamics (CFD) analysis was performed.
RESULTS: The presence of C7 aneurysms was associated with the height of the C4-C6 curved arteries (odds ratio [OR] 0.028, 95% confidence interval [CI] 0.003-0.201; P < 0.001). The heights of the C4-C6 curved arteries in the aneurysm group were significantly shorter than those in the control group. The CFD analysis revealed that shorter C4-C6 bends led to greater blood velocity and pressure in the C7 segment arteries.
CONCLUSIONS: A shorter C4-C6 bend was associated with distal C7 aneurysm formation, and an elaborate hemodynamic mechanism may underlie this association.
METHODS: In this study 32 patients with C7 aneurysms diagnosed at Xiangya Hospital between 2019 and 2021 and 32 control subjects were enrolled after propensity score matching. Computed tomography angiography (CTA) images were acquired to measure morphologic features, and then, by combining clinical data, simplified carotid siphon models were constructed, and computational fluid dynamics (CFD) analysis was performed.
RESULTS: The presence of C7 aneurysms was associated with the height of the C4-C6 curved arteries (odds ratio [OR] 0.028, 95% confidence interval [CI] 0.003-0.201; P < 0.001). The heights of the C4-C6 curved arteries in the aneurysm group were significantly shorter than those in the control group. The CFD analysis revealed that shorter C4-C6 bends led to greater blood velocity and pressure in the C7 segment arteries.
CONCLUSIONS: A shorter C4-C6 bend was associated with distal C7 aneurysm formation, and an elaborate hemodynamic mechanism may underlie this association.
摘要：
目的：颈内动脉（ICA）的弯曲与颅内动脉瘤（IAs）有关。虹吸管是ICA中最弯曲的部分，但其形态对IAs有争议的影响。本研究旨在探讨虹吸管的形态特征以及可能影响C7动脉瘤形成的潜在血液动力学机制。
方法：本研究中，湘雅医院在2019年至2021年诊断为C7动脉瘤的32例患者和32名对照受试者，经过倾向评分匹配。获取计算机断层扫描血管造影（CTA）图像以测量形态学特征，然后,通过结合临床数据，构建了简化的颈动脉虹吸模型，并进行了计算流体力学(CFD)分析。
结果：C7动脉瘤的存在与C4-C6弯曲动脉的高度相关（比值比[OR]0.028，95％置信区间[CI]0.003-0.201；P<0.001）。动脉瘤组的C4-C6弯曲动脉的高度明显短于对照组。CFD分析显示，较短的C4-C6弯曲导致C7段动脉中更大的血流速度和压力。
结论：较短的C4-C6弯曲与远端C7动脉瘤形成有关，而复杂的血液动力学机制可能是这种关联的基础。
方法：本研究中，湘雅医院在2019年至2021年诊断为C7动脉瘤的32例患者和32名对照受试者，经过倾向评分匹配。获取计算机断层扫描血管造影（CTA）图像以测量形态学特征，然后,通过结合临床数据，构建了简化的颈动脉虹吸模型，并进行了计算流体力学(CFD)分析。
结果：C7动脉瘤的存在与C4-C6弯曲动脉的高度相关（比值比[OR]0.028，95％置信区间[CI]0.003-0.201；P<0.001）。动脉瘤组的C4-C6弯曲动脉的高度明显短于对照组。CFD分析显示，较短的C4-C6弯曲导致C7段动脉中更大的血流速度和压力。
结论：较短的C4-C6弯曲与远端C7动脉瘤形成有关，而复杂的血液动力学机制可能是这种关联的基础。
