Abstract：
OBJECTIVE: Patients with systemic scleroderma (SSc) often suffer from premature tooth loss. The aim of this study was to radiologically investigate bone loss at dental implants in patients with SSc and compare it with data from the literature on healthy patients.
METHODS: Mesial and distal bone level changes at implants were independently determined on panoramic and intraoral radiographs. They were double-checked after determination of evaluability by three different raters. Cohen\'s kappa was used to test for interrater reliability. Mean bone loss was estimated using linear regression analysis considering the patient as a random-effect implant and performed separately in predefined implant regions for different time points and for the mesial and distal sides of the implants.
RESULTS: Mesial and distal bone level changes were analyzed in 61 implants using periapical and panoramic radiographs. In total, 114 radiographs from 18 patients were evaluable in both the mesial and distal regions. After a maximum observation period of 60 months, the mean peri-implant bone loss was 1.68 mm (range: 0.83 to 2.54 mm) at the distal aspect and 1.65 mm (range: 0.81 to 2.48 mm) at the mesial aspect in the right posterior mandible (region 44 to 47 [FDI numbering system]), whereas in the left posterior maxilla (regions 24 to 27), the mean peri-implant bone loss was 0.61 mm (range: 0.32 to 0.91 mm) at the distal aspect and 0.59 mm (range: 0.16 to 1.03 mm) at the mesial aspect. The mean bone loss 60 months after surgery was 1.05 mm (range: 0.85 to 1.25 mm).
CONCLUSIONS: Marginal bone loss at implants in patients with SSc is comparable to data from the literature collected in healthy subjects.
METHODS: Mesial and distal bone level changes at implants were independently determined on panoramic and intraoral radiographs. They were double-checked after determination of evaluability by three different raters. Cohen\'s kappa was used to test for interrater reliability. Mean bone loss was estimated using linear regression analysis considering the patient as a random-effect implant and performed separately in predefined implant regions for different time points and for the mesial and distal sides of the implants.
RESULTS: Mesial and distal bone level changes were analyzed in 61 implants using periapical and panoramic radiographs. In total, 114 radiographs from 18 patients were evaluable in both the mesial and distal regions. After a maximum observation period of 60 months, the mean peri-implant bone loss was 1.68 mm (range: 0.83 to 2.54 mm) at the distal aspect and 1.65 mm (range: 0.81 to 2.48 mm) at the mesial aspect in the right posterior mandible (region 44 to 47 [FDI numbering system]), whereas in the left posterior maxilla (regions 24 to 27), the mean peri-implant bone loss was 0.61 mm (range: 0.32 to 0.91 mm) at the distal aspect and 0.59 mm (range: 0.16 to 1.03 mm) at the mesial aspect. The mean bone loss 60 months after surgery was 1.05 mm (range: 0.85 to 1.25 mm).
CONCLUSIONS: Marginal bone loss at implants in patients with SSc is comparable to data from the literature collected in healthy subjects.
摘要：
目的：系统性硬皮病（SSc）患者常出现牙齿早衰。这项研究的目的是通过放射学研究SSc患者牙科植入物的骨丢失，并将其与健康患者文献中的数据进行比较。
方法：在全景和口内X线片上独立确定植入物的内侧和远端骨水平变化。在三个不同的评估者确定可评估性后，对它们进行了双重检查。科恩的卡帕被用来检验评估者间的可靠性。使用线性回归分析将患者视为随机效应植入物来估计平均骨丢失，并在不同时间点的预定义植入物区域以及植入物的内侧和远侧分别进行。
结果：使用根尖周和全景X线片分析了61个植入物的内侧和远端骨水平变化。总的来说,在内侧和远端区域均可评估来自18例患者的114张X射线照片。经过60个月的最长观察期，平均种植体周围骨丢失在远端为1.68mm（范围：0.83至2.54mm），在右后下颌骨的内侧为1.65mm（范围：0.81至2.48mm）（区域44至47[FDI编号系统]），而在左后上颌骨（区域24至27），种植体周围骨丢失在远端为0.61mm(范围:0.32~0.91mm),在近端为0.59mm(范围:0.16~1.03mm).术后60个月平均骨丢失为1.05mm（范围：0.85至1.25mm）。
结论：SSc患者植入物的边缘性骨丢失与健康受试者收集的文献数据相当。
方法：在全景和口内X线片上独立确定植入物的内侧和远端骨水平变化。在三个不同的评估者确定可评估性后，对它们进行了双重检查。科恩的卡帕被用来检验评估者间的可靠性。使用线性回归分析将患者视为随机效应植入物来估计平均骨丢失，并在不同时间点的预定义植入物区域以及植入物的内侧和远侧分别进行。
结果：使用根尖周和全景X线片分析了61个植入物的内侧和远端骨水平变化。总的来说,在内侧和远端区域均可评估来自18例患者的114张X射线照片。经过60个月的最长观察期，平均种植体周围骨丢失在远端为1.68mm（范围：0.83至2.54mm），在右后下颌骨的内侧为1.65mm（范围：0.81至2.48mm）（区域44至47[FDI编号系统]），而在左后上颌骨（区域24至27），种植体周围骨丢失在远端为0.61mm(范围:0.32~0.91mm),在近端为0.59mm(范围:0.16~1.03mm).术后60个月平均骨丢失为1.05mm（范围：0.85至1.25mm）。
结论：SSc患者植入物的边缘性骨丢失与健康受试者收集的文献数据相当。
