PDF(Pubmed)
Abstract：
UNASSIGNED: Malignant melanoma most commonly occurs in the skin. Primary malignant melanoma of endometrium is quite rare. Its diagnosis depends on clinical characteristics and pathological examination. It usually exhibits high degree of tumor histology, early onset of distant metastases, and unfavorable prognoses.
UNASSIGNED: In this paper, we report a case of a 73-year-old woman with primary malignant melanoma of endometrium. This patient denied a history of nevus removal or any family medical history of cancer. She was admitted to the hospital for irregular vaginal bleeding after menopause and performed an endometrial biopsy. Pathological of the scrapings suggested malignant melanoma. She subsequently underwent a radical surgery. The final pathology diagnosis was primary malignant melanoma of endometrium, and BRAF gene mutation was detected. The tumor staged as IVB according to the International Federation of Gynecology and Obstetrics (FIGO) classification. Thus, she then started adjuvant chemotherapy. This patient is currently on oral targeted therapy and is still being followed up.
UNASSIGNED: Mucosal melanoma is infrequent, and primary malignant melanoma of endometrial is a rare subtype. To the best of our knowledge, malignant melanoma originating from endometrium has never been reported before. It has a high degree of malignancy and is prone to early metastasis. Further investigations are warranted to explore its underlying pathogenesis, management, and outcomes.
UNASSIGNED: In this paper, we report a case of a 73-year-old woman with primary malignant melanoma of endometrium. This patient denied a history of nevus removal or any family medical history of cancer. She was admitted to the hospital for irregular vaginal bleeding after menopause and performed an endometrial biopsy. Pathological of the scrapings suggested malignant melanoma. She subsequently underwent a radical surgery. The final pathology diagnosis was primary malignant melanoma of endometrium, and BRAF gene mutation was detected. The tumor staged as IVB according to the International Federation of Gynecology and Obstetrics (FIGO) classification. Thus, she then started adjuvant chemotherapy. This patient is currently on oral targeted therapy and is still being followed up.
UNASSIGNED: Mucosal melanoma is infrequent, and primary malignant melanoma of endometrial is a rare subtype. To the best of our knowledge, malignant melanoma originating from endometrium has never been reported before. It has a high degree of malignancy and is prone to early metastasis. Further investigations are warranted to explore its underlying pathogenesis, management, and outcomes.
摘要：
■恶性黑色素瘤最常见于皮肤。原发性子宫内膜恶性黑色素瘤相当罕见。其诊断取决于临床特征和病理检查。它通常表现出高度的肿瘤组织学，远处转移的早期发作，和不利的预后。
■在本文中，我们报告一例73岁女性原发性子宫内膜恶性黑色素瘤。该患者否认痣切除史或任何癌症家族史。她因绝经后不规则阴道出血入院，并进行了子宫内膜活检。刮片的病理提示恶性黑色素瘤。随后，她接受了根治性手术。最终病理诊断为原发性子宫内膜恶性黑色素瘤，检测到BRAF基因突变。根据国际妇产科联合会（FIGO）分类，肿瘤分期为IVB。因此，然后她开始辅助化疗。该患者目前正在口服靶向治疗，仍在随访中。
■粘膜黑色素瘤很少见，原发性子宫内膜恶性黑色素瘤是一种罕见的亚型。据我们所知,以前从未报道过源自子宫内膜的恶性黑色素瘤。恶性程度高，易发生早期转移。需要进一步的研究来探索其潜在的发病机制，管理,和结果。
■在本文中，我们报告一例73岁女性原发性子宫内膜恶性黑色素瘤。该患者否认痣切除史或任何癌症家族史。她因绝经后不规则阴道出血入院，并进行了子宫内膜活检。刮片的病理提示恶性黑色素瘤。随后，她接受了根治性手术。最终病理诊断为原发性子宫内膜恶性黑色素瘤，检测到BRAF基因突变。根据国际妇产科联合会（FIGO）分类，肿瘤分期为IVB。因此，然后她开始辅助化疗。该患者目前正在口服靶向治疗，仍在随访中。
■粘膜黑色素瘤很少见，原发性子宫内膜恶性黑色素瘤是一种罕见的亚型。据我们所知,以前从未报道过源自子宫内膜的恶性黑色素瘤。恶性程度高，易发生早期转移。需要进一步的研究来探索其潜在的发病机制，管理,和结果。
