PDF(Pubmed)
Abstract：
Dyslexia is a genetic and heritable disorder that has yet to discover the treatment of it, especially at the molecular and drug intervention levels. This review provides an overview of the current findings on the environmental and genetic factors involved in developmental dyslexia. The latest techniques used in diagnosing the disease and macromolecular factors findings may contribute to a higher degree of development in detangling the proper management and treatment for dyslexic individuals. Furthermore, this review tried to put together all the models used in the current dyslexia research for references in future studies that include animal models as well as in vitro models and how the previous research has provided consistent data across many years and regions. Thus, we suggest furthering the studies using an organoid model based on the existing gene polymorphism, pathways, and neuronal function input.
摘要：
阅读障碍是一种遗传和遗传性疾病，尚未发现治疗方法，特别是在分子和药物干预水平。这篇综述概述了有关发育性阅读障碍的环境和遗传因素的最新发现。用于诊断疾病的最新技术和大分子因素的发现可能有助于在解决阅读障碍者的适当管理和治疗方面取得更高的发展。此外，这篇综述试图将目前阅读障碍研究中使用的所有模型放在一起，供未来研究参考，包括动物模型和体外模型，以及以前的研究如何在多年和地区提供一致的数据。因此，我们建议使用基于现有基因多态性的类器官模型进一步研究，通路,和神经元功能输入。
