PDF(Pubmed)
Abstract：
The connection between the triglyceride-glucose index (TyG index) and gestational diabetes mellitus (GDM) is currently debated. Our study aimed to investigate the connection between the TyG index and GDM within the Korean population.
Using publically accessible data in Korea, we performed a secondary study on a sample of 589 pregnant women who were carrying a single fetus. The analysis employed a binary logistic regression model, some sensitivity analyses, and subgroup analysis to investigate the association between the TyG index and the occurrence of GDM. To assess the TyG index\'s potential to predict GDM, a receiver operating characteristic (ROC) study was also carried out.
The mean age of the pregnant women was 32.065 ± 3.798 years old, while the mean TyG index was 8.352 ± 0.400. The prevalence rate of GDM was found to be 6.112%. Upon adjusting for potential confounding variables, a positive association was detected between the TyG index and incident GDM (OR = 12.923, 95%CI: 3.581-46.632, p = 0.00009). The validity of this connection was further confirmed by subgroup analysis and sensitivity analyses. With an area under the ROC curve of 0.807 (95%CI: 0.734-0.879), the TyG index showed strong predictive power for GDM. The TyG index\'s ideal cutoff value for detecting GDM was found to be 8.632, with a sensitivity of 78.7% and a specificity of 72.2%.
The findings of our study provide evidence that an increased TyG index is significantly associated with the occurrence of GDM. Utilizing the TyG index during the 10-14 week gestational period may be a valuable tool in identifying pregnant individuals at a heightened risk for developing GDM. Early detection enables timely and efficacious interventions, thereby enhancing the prognosis of affected individuals.
Using publically accessible data in Korea, we performed a secondary study on a sample of 589 pregnant women who were carrying a single fetus. The analysis employed a binary logistic regression model, some sensitivity analyses, and subgroup analysis to investigate the association between the TyG index and the occurrence of GDM. To assess the TyG index\'s potential to predict GDM, a receiver operating characteristic (ROC) study was also carried out.
The mean age of the pregnant women was 32.065 ± 3.798 years old, while the mean TyG index was 8.352 ± 0.400. The prevalence rate of GDM was found to be 6.112%. Upon adjusting for potential confounding variables, a positive association was detected between the TyG index and incident GDM (OR = 12.923, 95%CI: 3.581-46.632, p = 0.00009). The validity of this connection was further confirmed by subgroup analysis and sensitivity analyses. With an area under the ROC curve of 0.807 (95%CI: 0.734-0.879), the TyG index showed strong predictive power for GDM. The TyG index\'s ideal cutoff value for detecting GDM was found to be 8.632, with a sensitivity of 78.7% and a specificity of 72.2%.
The findings of our study provide evidence that an increased TyG index is significantly associated with the occurrence of GDM. Utilizing the TyG index during the 10-14 week gestational period may be a valuable tool in identifying pregnant individuals at a heightened risk for developing GDM. Early detection enables timely and efficacious interventions, thereby enhancing the prognosis of affected individuals.
摘要：
■目前正在争论甘油三酸酯-葡萄糖指数（TyG指数）与妊娠糖尿病（GDM）之间的联系。我们的研究旨在调查韩国人群中TyG指数与GDM之间的联系。
■在韩国使用可公开访问的数据，我们对589例携带单个胎儿的孕妇进行了二次研究.分析采用二元逻辑回归模型，一些敏感性分析，亚组分析探讨TyG指数与GDM发生的相关性。为了评估TyG指数预测GDM的潜力，还进行了接收器工作特性（ROC）研究。
■孕妇的平均年龄为32.065±3.798岁，而平均TyG指数为8.352±0.400。GDM的患病率为6.112%。在调整潜在的混杂变量后，TyG指数与GDM呈正相关(OR=12.923,95CI:3.581-46.632,p=0.00009).亚组分析和敏感性分析进一步证实了这种联系的有效性。ROC曲线下面积为0.807（95CI：0.734-0.879），TyG指数对GDM有较强的预测能力。发现TyG指数检测GDM的理想截断值为8.632，灵敏度为78.7%，特异性为72.2%。
■我们的研究结果提供了证据，表明TyG指数增加与GDM的发生显着相关。在妊娠10-14周期间利用TyG指数可能是鉴定处于发生GDM的高风险的怀孕个体的有价值的工具。早期检测能够实现及时有效的干预，从而增强受影响个体的预后。
■在韩国使用可公开访问的数据，我们对589例携带单个胎儿的孕妇进行了二次研究.分析采用二元逻辑回归模型，一些敏感性分析，亚组分析探讨TyG指数与GDM发生的相关性。为了评估TyG指数预测GDM的潜力，还进行了接收器工作特性（ROC）研究。
■孕妇的平均年龄为32.065±3.798岁，而平均TyG指数为8.352±0.400。GDM的患病率为6.112%。在调整潜在的混杂变量后，TyG指数与GDM呈正相关(OR=12.923,95CI:3.581-46.632,p=0.00009).亚组分析和敏感性分析进一步证实了这种联系的有效性。ROC曲线下面积为0.807（95CI：0.734-0.879），TyG指数对GDM有较强的预测能力。发现TyG指数检测GDM的理想截断值为8.632，灵敏度为78.7%，特异性为72.2%。
■我们的研究结果提供了证据，表明TyG指数增加与GDM的发生显着相关。在妊娠10-14周期间利用TyG指数可能是鉴定处于发生GDM的高风险的怀孕个体的有价值的工具。早期检测能够实现及时有效的干预，从而增强受影响个体的预后。
