Abstract：
Previous studies have reported swimming, atopic dermatitis, and filaggrin (FLG) gene mutations as risk factors for molluscum contagiosum (MC) infection. FLG gene mutations impair skin barrier function. The aim of this study was to determine the impact of FLG mutations on the incidence and clinical features of MC. We used data from 2036 children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children\'s Study, a prospective, birth cohort study. A questionnaire for caregivers (when children were 4 and 8 years of age) asked about clinical features including previous MC incidence and treatment, number of MC lesions at first visit, and time to resolution. Participants underwent genotyping to detect six FLG mutations that are common in the Japanese population. A logistic regression model was used to analyze the association between MC incidence and FLG mutations, adjusted for potential confounders. The cumulative incidence of MC at age 8 years was 47.1%. Among participants with a history of MC, 67.6% had undergone curettage. FLG mutation was a significant risk factor for MC incidence (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.18-2.42). Swimming and atopic dermatitis were also significant risk factors for MC. There was no significant association between FLG mutation and the number of MC lesions at the first visit or the time to resolution of lesions. FLG mutation is a risk factor for MC incidence; however, FLG mutations do not affect the number of MC lesions at presentation or the time to resolution.
摘要：
以前的研究报道了游泳，特应性皮炎,丝聚蛋白（FLG）基因突变是传染性软疣（MC）感染的危险因素。FLG基因突变损害皮肤屏障功能。这项研究的目的是确定FLG突变对MC的发生率和临床特征的影响。我们使用的数据来自2036名儿童，他们参加了山梨县附属研究的日本环境和儿童研究，一个潜在的，出生队列研究。针对照顾者的问卷（当儿童为4岁和8岁时）询问了临床特征，包括以前的MC发生率和治疗，首次就诊时的MC病变数量，和时间来解决。参与者进行基因分型以检测在日本人群中常见的6种FLG突变。采用logistic回归模型分析MC发病率与FLG突变的相关性,针对潜在的混杂因素进行了调整。8岁时MC的累积发生率为47.1％。在有MC历史的参与者中，67.6％进行了刮宫。FLG突变是MC发生率的重要危险因素（校正比值比[aOR]1.69，95%置信区间[CI]1.18-2.42）。游泳和特应性皮炎也是MC的重要危险因素。FLG突变与首次就诊时的MC病变数量或病变消退时间之间没有显着关联。FLG突变是MC发病的危险因素；然而，FLG突变不影响出现时MC病变的数量或消退时间。
