PDF(Pubmed)
Abstract：
Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. Therefore, the aim of this study was to assess the effects of hypermobile Ehlers Danlos Syndrome on lower extremity gait mechanics and muscle strength.
Eleven people with hypermobile Ehlers Danlos Syndrome and 11 asymptomatic controls underwent a 3D gait analysis and isometric hip and knee muscle strength assessment. Joint subluxations were self-reported by the hypermobile Ehlers Danlos syndrome group. Independent t-tests and Mann Whitney U tests were used to analyze joint mechanics, muscle strength, and patient report outcomes (p < 0.05).
Both groups exhibited similar walking speeds as well as similar hip, knee, and ankle joint kinematics. The hypermobile Ehlers Danlos Syndrome group walked with a lower peak hip extensor moment (hypermobile Ehlers Danlos Syndrome: -0.52 ± 0.28 Nmˑkg-1, Control: -0.83 ± 0.26 Nmˑkg-1, p = 0.01) yet similar knee and ankle joint moments. The hypermobile Ehlers Danlos Syndrome group exhibited a 40% deficit in peak hip extensor strength (hypermobile Ehlers Danlos Syndrome:1.07 ± 0.53 Nmˑkg-1, Control: 1.77 ± 0.79 Nmˑkg-1, p = 0.04). Approximately 73%, 55% and 45% of the hypermobile Ehlers Danlos Syndrome cohort self-reported hip, knee/patella and ankle joint subluxations, respectively, at least once a week.
Patients with hypermobile Ehlers Danlos Syndrome ambulated with altered hip extensor moments and exhibit hip extensor weakness. Future work should investigate the underlying mechanisms of hip extensor weakness and corresponding effects on joint health in people with hypermobile Ehlers Danlos Syndrome.
Eleven people with hypermobile Ehlers Danlos Syndrome and 11 asymptomatic controls underwent a 3D gait analysis and isometric hip and knee muscle strength assessment. Joint subluxations were self-reported by the hypermobile Ehlers Danlos syndrome group. Independent t-tests and Mann Whitney U tests were used to analyze joint mechanics, muscle strength, and patient report outcomes (p < 0.05).
Both groups exhibited similar walking speeds as well as similar hip, knee, and ankle joint kinematics. The hypermobile Ehlers Danlos Syndrome group walked with a lower peak hip extensor moment (hypermobile Ehlers Danlos Syndrome: -0.52 ± 0.28 Nmˑkg-1, Control: -0.83 ± 0.26 Nmˑkg-1, p = 0.01) yet similar knee and ankle joint moments. The hypermobile Ehlers Danlos Syndrome group exhibited a 40% deficit in peak hip extensor strength (hypermobile Ehlers Danlos Syndrome:1.07 ± 0.53 Nmˑkg-1, Control: 1.77 ± 0.79 Nmˑkg-1, p = 0.04). Approximately 73%, 55% and 45% of the hypermobile Ehlers Danlos Syndrome cohort self-reported hip, knee/patella and ankle joint subluxations, respectively, at least once a week.
Patients with hypermobile Ehlers Danlos Syndrome ambulated with altered hip extensor moments and exhibit hip extensor weakness. Future work should investigate the underlying mechanisms of hip extensor weakness and corresponding effects on joint health in people with hypermobile Ehlers Danlos Syndrome.
摘要：
背景：HypermobileEhlersDanlos综合征，遗传性结缔组织疾病,与肌肉功能障碍有关，关节半脱位和疼痛。高度移动的EhlersDanlos综合征对肌肉骨骼力学的影响尚未研究。因此,这项研究的目的是评估超活动EhlersDanlos综合征对下肢步态力学和肌肉力量的影响。
方法：11名患有高流动性EhlersDanlos综合征的患者和11名无症状对照者接受了3D步态分析和等距髋和膝关节肌力评估。关节半脱位由超机动EhlersDanlos综合征组自我报告。独立t检验和MannWhitneyU检验用于分析关节力学，肌肉力量,和患者报告结果（p<0.05）。
结果：两组均表现出相似的步行速度和相似的臀部，膝盖,和踝关节运动学。超活动EhlersDanlos综合征组以较低的峰值髋关节伸肌力矩行走（超活动EhlersDanlos综合征：-0.52±0.28Nmkg-1，对照：-0.83±0.26Nmkg-1，p=0.01）相似的膝关节和踝关节力矩。超活动EhlersDanlos综合征组的髋关节伸肌强度峰值不足40％（超活动EhlersDanlos综合征：1.07±0.53Nmkg-1，对照：1.77±0.79Nmkg-1，p=0.04）。约73%,55%和45%的高流动性EhlersDanlos综合征队列自我报告髋关节，膝关节/髌骨和踝关节半脱位,分别,至少每周一次.
结论：超活动EhlersDanlos综合征患者因髋关节伸肌力矩改变而行走并表现为髋关节伸肌无力。未来的工作应该研究髋关节伸肌无力的潜在机制以及对高流动性EhlersDanlos综合征患者关节健康的相应影响。
方法：11名患有高流动性EhlersDanlos综合征的患者和11名无症状对照者接受了3D步态分析和等距髋和膝关节肌力评估。关节半脱位由超机动EhlersDanlos综合征组自我报告。独立t检验和MannWhitneyU检验用于分析关节力学，肌肉力量,和患者报告结果（p<0.05）。
结果：两组均表现出相似的步行速度和相似的臀部，膝盖,和踝关节运动学。超活动EhlersDanlos综合征组以较低的峰值髋关节伸肌力矩行走（超活动EhlersDanlos综合征：-0.52±0.28Nm
结论：超活动EhlersDanlos综合征患者因髋关节伸肌力矩改变而行走并表现为髋关节伸肌无力。未来的工作应该研究髋关节伸肌无力的潜在机制以及对高流动性EhlersDanlos综合征患者关节健康的相应影响。
