Abstract：
OBJECTIVE: This study aimed to assess the relative growth rates (RGRs) of the maxilla and mandible at varying fusion stages of the spheno-occipital synchondrosis (SOS), thereby elucidating the potential of SOS stages in predicting maxillomandibular growth.
METHODS: A total of 320 subjects (171 boys and 149 girls), aged 6 to 18 years, were retrospectively included. Each subject had a minimum of two longitudinal cone-beam computed tomography (CBCT) images, with no more than one interval of SOS fusion stage change between the two scans. Subjects were categorized based on their SOS fusion stages and genders. The RGRs of the maxilla and mandible at various SOS fusion stages were measured and compared using longitudinal CBCT images.
RESULTS: Significant statistical differences were observed in maxillomandibular RGRs across various SOS fusion stages. In girls, the sagittal growth of the maxilla remained stable and active until SOS 3, subsequently exhibited deceleration in SOS 4-5 (compared to SOS 3-4, P < .05) and continued to decrease in SOS 5-6. Whereas in boys, the sagittal growth of the maxilla remained stable until SOS 4, and a deceleration trend emerged starting from SOS 5 to 6 (P < .01 compared to SOS 4-5). Mandibular growth patterns in both genders exhibited a progression of increasing-accelerating-decelerating rates from SOS 2 to 6. The highest RGRs for total mandibular length were observed in SOS 3-4 and SOS 4-5.
CONCLUSIONS: Spheno-occipital synchondrosis fusion stages can serve as a valid indicator of maxillomandibular growth maturation.
METHODS: A total of 320 subjects (171 boys and 149 girls), aged 6 to 18 years, were retrospectively included. Each subject had a minimum of two longitudinal cone-beam computed tomography (CBCT) images, with no more than one interval of SOS fusion stage change between the two scans. Subjects were categorized based on their SOS fusion stages and genders. The RGRs of the maxilla and mandible at various SOS fusion stages were measured and compared using longitudinal CBCT images.
RESULTS: Significant statistical differences were observed in maxillomandibular RGRs across various SOS fusion stages. In girls, the sagittal growth of the maxilla remained stable and active until SOS 3, subsequently exhibited deceleration in SOS 4-5 (compared to SOS 3-4, P < .05) and continued to decrease in SOS 5-6. Whereas in boys, the sagittal growth of the maxilla remained stable until SOS 4, and a deceleration trend emerged starting from SOS 5 to 6 (P < .01 compared to SOS 4-5). Mandibular growth patterns in both genders exhibited a progression of increasing-accelerating-decelerating rates from SOS 2 to 6. The highest RGRs for total mandibular length were observed in SOS 3-4 and SOS 4-5.
CONCLUSIONS: Spheno-occipital synchondrosis fusion stages can serve as a valid indicator of maxillomandibular growth maturation.
摘要：
目的：本研究旨在评估不同融合阶段的蝶枕骨联合软骨病（SOS）上颌骨和下颌骨的相对生长速率（RGR）。从而阐明SOS阶段在预测上颌下颌生长方面的潜力。
方法：共320名受试者（171名男孩和149名女孩），6至18岁，被回顾性地包括在内。每个受试者至少有两张纵向锥形束计算机断层扫描（CBCT）图像，两次扫描之间的SOS融合阶段变化不超过一个间隔。根据SOS融合阶段和性别对受试者进行分类。使用纵向CBCT图像测量并比较了上颌骨和下颌骨在各个SOS融合阶段的RGR。
结果：在不同的SOS融合阶段，观察到上颌下颌RGR的统计学差异。在女孩中，上颌骨的矢状生长保持稳定和活跃，直到SOS3，随后在SOS4-5中表现出减速（与SOS3-4相比，P<.05），并在SOS5-6中继续下降。而在男孩中，直到SOS4，上颌骨的矢状生长保持稳定，并且从SOS5到6开始出现减速趋势（与SOS4-5相比，P<0.01）。两种性别的下颌骨生长方式均表现出从SOS2到6的加速减速速率增加。在SOS3-4和SOS4-5中观察到下颌总长度的最高RGR。
结论：枕骨联合软骨融合阶段可以作为上颌下颌发育成熟的有效指标。
方法：共320名受试者（171名男孩和149名女孩），6至18岁，被回顾性地包括在内。每个受试者至少有两张纵向锥形束计算机断层扫描（CBCT）图像，两次扫描之间的SOS融合阶段变化不超过一个间隔。根据SOS融合阶段和性别对受试者进行分类。使用纵向CBCT图像测量并比较了上颌骨和下颌骨在各个SOS融合阶段的RGR。
结果：在不同的SOS融合阶段，观察到上颌下颌RGR的统计学差异。在女孩中，上颌骨的矢状生长保持稳定和活跃，直到SOS3，随后在SOS4-5中表现出减速（与SOS3-4相比，P<.05），并在SOS5-6中继续下降。而在男孩中，直到SOS4，上颌骨的矢状生长保持稳定，并且从SOS5到6开始出现减速趋势（与SOS4-5相比，P<0.01）。两种性别的下颌骨生长方式均表现出从SOS2到6的加速减速速率增加。在SOS3-4和SOS4-5中观察到下颌总长度的最高RGR。
结论：枕骨联合软骨融合阶段可以作为上颌下颌发育成熟的有效指标。
