关键词: ependymoma fluorescence in situ hybridization (FISH) gross total resection (GTR) meningioma (disrupted in balanced translocation) 1 (MN1) spinal astroblastoma

Mesh : Humans Neoplasms, Neuroepithelial / pathology genetics diagnostic imaging Child, Preschool Tumor Suppressor Proteins / genetics Spinal Cord Neoplasms / pathology genetics diagnostic imaging Male Female Trans-Activators

来  源:   DOI:10.1111/neup.12965

Abstract:
Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low- and high-grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.
摘要:
星形母细胞瘤是一种罕见的局限性神经胶质肿瘤,主要累及大脑半球。特征性分子改变是脑膜瘤(在平衡易位中被破坏)1(MN1)重排。尚未确定世界卫生组织的等级,因为已知会发生低级和高级肿瘤。脊柱肿瘤极为罕见;迄今为止,文献中仅报道了三例。当肿瘤出现在不寻常的位置时,警惕的显微镜和辅助测试有助于诊断,就像我们的情况一样。由于管理方式不同且尚未明确建立,因此必须迅速将该肿瘤与其模拟物区分开。
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