PDF(Pubmed)
Abstract：
Spontaneous subgaleal hematoma in pediatric patients with sickle cell disease (SCD) is a rare occurrence that can present with symptoms mimicking ischemic stroke, a known complication of SCD. However, unlike ischemic stroke, subgaleal hematoma is nonlethal and can be managed conservatively without major sequelae. Here, we present the case of an adolescent with SCD who presented with 2 episodes of subgaleal and epidural hematomas, 2 years apart. The latter episode occurred while on crizanlizumab, an anti-P-selectin antibody, approved for use in SCD in 2019 to reduce the number of acute pain crises. We demonstrate the diagnosis of subgaleal hematoma and outline steps to conservative management which were safe and did not lead to focal neurologic deficits.
摘要：
患有镰状细胞病（SCD）的儿科患者的自发性盖下血肿是罕见的，可以表现为模仿缺血性中风的症状，SCD的已知并发症。然而,与缺血性中风不同，盖下血肿是非致死性的，可以保守治疗，没有严重的后遗症。这里,我们介绍了一个青少年SCD的病例，他出现了2次皮下和硬膜外血肿，相隔2年。后一种情况发生在使用crizanlizumab时，抗P-选择素抗体,2019年批准用于SCD，以减少急性疼痛危机的数量。我们证明了腹膜下血肿的诊断，并概述了保守治疗的步骤，这些步骤是安全的，不会导致局灶性神经功能缺损。
