Abstract：
For many years, the synthesis of graphene oxide (GO) had involved exfoliating graphite flakes, and the methods applied were expensive and time-consuming. Thus, an attempt had been made to create an inventive, less expensive method for the synthesis of GO using unrefined, raw carbon-containing material. Modified Hummer\'s method was used to prepare GO from banana peel. In addition, the metallic silver nanocomposite was also synthesized along with laoding of drug Rocephin where they interact with each other through electrostatic hydrogen bond interaction. The degree of crystallinity and the crystallite size were through x-ray diffraction (XRD) analysis and the crystallite size of AgNPs was found to be 40.40 nm. The scanning electron microscopy (SEM) analysis shows that the morphology of the GO gradually changes with the addition of AgNPs and Rocephin. A blue shift was seen in the absorbance maxima of the raw carbon upon the conjugation of Rocephin in UV analysis. The Fourier-transform infrared spectroscopy, and energy dispersive X-ray (EDX) spectroscopy were used to determine the chemical composition of the samples. Furthermore, a broad biological screening of the synthesized samples had been carried out following the total reducing power (TRP), total antioxidant capacity (TAC), antibacterial, antifungal, MTT (Cytotoxicity of biologically synthesized silver nanoparticles in MDA-MB-231 human breast cancer cells) cell viability, brine shrimp lethality, and hemolytic protocols. Significant results were obtained, and the Rocephin-GO-AgNPs had depicted promising activity as compared with their counterparts. RESEARCH HIGHLIGHTS: The GO was prepared from the raw carbon extracted from banana peels and was used as a substrate for the synthesis Graphene oxide silver nanoparticles (GO-AgNPs) and Rocephin-loaded graphene oxide silver nanoparticles (Rocephin-GO-AgNPs) The structural and compositional analysis of the nanomaterial was carried out, and they were screened for several biomedical applications. The Rocephin-GO-AgNPs exhibit the highest activity as compared with their counterparts.
摘要：
多年来,氧化石墨烯（GO）的合成涉及剥离石墨片，应用的方法昂贵且耗时。因此，试图创造一种发明，使用未精制的合成GO的成本较低的方法，原料含碳材料。采用改良的悍马方法从香蕉皮中制备GO。此外,金属银纳米复合材料还与药物Rocephin一起合成，它们通过静电氢键相互作用相互作用。结晶度和微晶尺寸通过X射线衍射(XRD)分析,发现AgNP的微晶尺寸为40.40nm。扫描电子显微镜（SEM）分析表明，随着AgNPs和Rocephin的加入，GO的形态逐渐发生变化。在UV分析中,当Rocephin共轭时,在原碳的吸光度最大值中观察到蓝移。傅里叶变换红外光谱,和能量色散X射线（EDX）光谱用于确定样品的化学成分。此外，在总还原能力（TRP）之后，对合成样品进行了广泛的生物筛选，总抗氧化能力(TAC)，抗菌，抗真菌药,MTT（生物合成银纳米颗粒对MDA-MB-231人乳腺癌细胞的细胞毒性）盐水虾的杀伤力，和溶血方案。取得了显著的成果,与Rocephin-GO-AgNPs相比，Rocephin-GO-AgNPs的活性很有希望。研究重点：GO是从香蕉皮中提取的原料碳制备的，并用作合成石墨烯氧化物银纳米颗粒（GO-AgNPs）和Rocephin负载的石墨烯氧化物银纳米颗粒（Rocephin-GO-AgNPs）的基材。进行了纳米材料的结构和组成分析，他们被筛选了几种生物医学应用。与它们的对应物相比,Rocephin-GO-AgNP表现出最高的活性。
