Abstract：
BACKGROUND: The purpose of the present meta-analysis was to systematically evaluate the effect of GnRHa treatment on the BMI of children with precocious puberty after GnRHa treatment as compared to before, and to analyze the effect of GnRHa treatment on the body composition of children with precocious puberty at different BMIs by classifying into normal body mass, overweight, and obese groups according to BMI at the time of initial diagnosis.
BACKGROUND: A meta-analysis was performed using Stata 12.0 software by searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), and Wan fang database for relevant literature on standard deviation score of body mass index (BMI-SDS) after GnRHa treatment as compared to before in children with precocious puberty.
CONCLUSIONS: A total of eight studies were included with a total sample size of 715 cases, and the results of meta-analysis showed that BMI-SDS increased in children with precocious puberty after GnRHa treatment as compared to before starting [(weighted mean difference (WMD)=0.23, 95 % CI: 0.14-0.33, p=0.000)] and also increased in children with normal body mass [(WMD=0.37, 95 % CI: 0.28-0.46, p=0.000)], and there was no significant change in BMI-SDS in children in the overweight or obese group [(WMD=0.01, 95 % CI: -0.08-0.10, p=0.775)].
CONCLUSIONS: Overall, there was an observed increase in BMI-SDS at the conclusion of GnRHa treatment in children with precocious puberty. Additionally, it was found that the effect of GnRHa treatment on body composition varied among children with different BMI status. Clinicians should emphasize the promotion of a healthy lifestyle and personalized dietary management for children.
BACKGROUND: A meta-analysis was performed using Stata 12.0 software by searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), and Wan fang database for relevant literature on standard deviation score of body mass index (BMI-SDS) after GnRHa treatment as compared to before in children with precocious puberty.
CONCLUSIONS: A total of eight studies were included with a total sample size of 715 cases, and the results of meta-analysis showed that BMI-SDS increased in children with precocious puberty after GnRHa treatment as compared to before starting [(weighted mean difference (WMD)=0.23, 95 % CI: 0.14-0.33, p=0.000)] and also increased in children with normal body mass [(WMD=0.37, 95 % CI: 0.28-0.46, p=0.000)], and there was no significant change in BMI-SDS in children in the overweight or obese group [(WMD=0.01, 95 % CI: -0.08-0.10, p=0.775)].
CONCLUSIONS: Overall, there was an observed increase in BMI-SDS at the conclusion of GnRHa treatment in children with precocious puberty. Additionally, it was found that the effect of GnRHa treatment on body composition varied among children with different BMI status. Clinicians should emphasize the promotion of a healthy lifestyle and personalized dietary management for children.
摘要：
背景：本荟萃分析的目的是系统评估GnRHa治疗后对性早熟儿童BMI的影响。并通过将GnRHa治疗分为正常体质量来分析不同BMI对性早熟儿童身体成分的影响，超重,根据初始诊断时的BMI和肥胖组。
背景：使用Stata12.0软件通过搜索PubMed进行了荟萃分析，Embase,WebofScience,科克伦图书馆,中国国家知识基础设施(CNKI),中国科学期刊数据库(VIP数据库),和万方数据库提供了有关GnRHa治疗后与性早熟儿童相比的体重指数标准偏差评分（BMI-SDS）的相关文献。
结论：共纳入8项研究，总样本量为715例，荟萃分析结果显示，与开始GnRHa治疗前相比，性早熟儿童的BMI-SDS增加[（加权平均差异（WMD）=0.23，95％CI：0.14-0.33，p=0.000）]，并且在体重正常的儿童中也增加[（WMD=0.37，95％CI：0.28-0.46，p=0.000）]，超重或肥胖组儿童BMI-SDS无显著变化[(WMD=0.01,95%CI:-0.08-0.10,p=0.775)]。
结论：总体而言，在性早熟的GnRHa治疗结束时,观察到BMI-SDS升高.此外,发现GnRHa治疗对身体成分的影响在具有不同BMI状态的儿童中有所不同。临床医生应强调促进儿童的健康生活方式和个性化饮食管理。
背景：使用Stata12.0软件通过搜索PubMed进行了荟萃分析，Embase,WebofScience,科克伦图书馆,中国国家知识基础设施(CNKI),中国科学期刊数据库(VIP数据库),和万方数据库提供了有关GnRHa治疗后与性早熟儿童相比的体重指数标准偏差评分（BMI-SDS）的相关文献。
结论：共纳入8项研究，总样本量为715例，荟萃分析结果显示，与开始GnRHa治疗前相比，性早熟儿童的BMI-SDS增加[（加权平均差异（WMD）=0.23，95％CI：0.14-0.33，p=0.000）]，并且在体重正常的儿童中也增加[（WMD=0.37，95％CI：0.28-0.46，p=0.000）]，超重或肥胖组儿童BMI-SDS无显著变化[(WMD=0.01,95%CI:-0.08-0.10,p=0.775)]。
结论：总体而言，在性早熟的GnRHa治疗结束时,观察到BMI-SDS升高.此外,发现GnRHa治疗对身体成分的影响在具有不同BMI状态的儿童中有所不同。临床医生应强调促进儿童的健康生活方式和个性化饮食管理。
