Abstract：
BACKGROUND: This study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT).
METHODS: Nine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed.
RESULTS: The cohort comprised four males and five females with a mean age of 48.1 years. The average proton dose administered during initial therapy was 68.5 Gy (relative biological effectiveness). Among the salvage surgeries, eight were anterior skull base surgeries, and one was an anterior middle skull base surgery. No local recurrences or perioperative deaths were observed. Postoperative complications occurred in three patients (33.3%), all experiencing surgical site infections, with one also having cerebrospinal fluid leakage.
CONCLUSIONS: The study demonstrates that salvage skull base surgery after PBT effectively achieves local control and safety in patients with recurrent sinonasal malignancies.
METHODS: Nine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed.
RESULTS: The cohort comprised four males and five females with a mean age of 48.1 years. The average proton dose administered during initial therapy was 68.5 Gy (relative biological effectiveness). Among the salvage surgeries, eight were anterior skull base surgeries, and one was an anterior middle skull base surgery. No local recurrences or perioperative deaths were observed. Postoperative complications occurred in three patients (33.3%), all experiencing surgical site infections, with one also having cerebrospinal fluid leakage.
CONCLUSIONS: The study demonstrates that salvage skull base surgery after PBT effectively achieves local control and safety in patients with recurrent sinonasal malignancies.
摘要：
背景：本研究旨在检查根治性质子束治疗（PBT）后与挽救性颅底手术相关的治疗结果和术后并发症。
方法：回顾性分析了2002年9月至2023年5月在我们机构接受根治性PBT作为初始治疗后接受了挽救性颅底手术的9例患者。
结果：该队列包括4名男性和5名女性，平均年龄为48.1岁。在初始治疗期间施用的平均质子剂量为68.5Gy(相对生物学有效性)。在抢救手术中，八个是前颅底手术，一个是前中颅底手术。没有观察到局部复发或围手术期死亡。术后并发症3例(33.3%),都经历过手术部位感染,其中一人也有脑脊液漏。
结论：该研究表明，在复发性鼻窦恶性肿瘤患者中，PBT后的颅底修复手术有效地实现了局部控制和安全性。
方法：回顾性分析了2002年9月至2023年5月在我们机构接受根治性PBT作为初始治疗后接受了挽救性颅底手术的9例患者。
结果：该队列包括4名男性和5名女性，平均年龄为48.1岁。在初始治疗期间施用的平均质子剂量为68.5Gy(相对生物学有效性)。在抢救手术中，八个是前颅底手术，一个是前中颅底手术。没有观察到局部复发或围手术期死亡。术后并发症3例(33.3%),都经历过手术部位感染,其中一人也有脑脊液漏。
结论：该研究表明，在复发性鼻窦恶性肿瘤患者中，PBT后的颅底修复手术有效地实现了局部控制和安全性。
